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US3970663A
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Certain amino-nicotinamide derivatives
Assignee: Science Union et Cie
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Filing: 1975-09-22
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Granted: 1976-07-20
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Expires: 1995-09-22
Abstract
Abstract Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH; n is O or 1 and R is ##EQU2## wherein: R 1 is hydrogen or methyl, R 2 and R 3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C 4 to C 7 optionally including an oxygen atom, and R' is saturated or unsaturated acyclic hydrocarbon radicals from C 1 to C 20 , cycloalkyl from C 3 to C 7 , Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C 1 to C 6 optionally including an oxygen atom, and Ar and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic. These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.
Inventors
- 👤 Gilbert Regnier
- 👤 Roger Canevari
- 👤 Xavier Pascaud
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:41
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/42; C07D403/00; C07D403/02; C07D403/12
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
220 words
A compound selected from the group consisting of : A. heterocyclic amides of the general formula I : ##SPC8## wherein: X is CH ; n is selected from 0 and 1, and R is selected from the group consisting of : ##EQU9## wherein : R 1 is selected from the group consisting of hydrogen and methyl, R 2 and R 3 joined together represent a polymethylenic chain of the formula -- (CH 2 ) p -- wherein p is an integer from 4 to 7 inclusive and R' is selected from the group consisting of saturated and unsaturated acyclic hydrocarbon radicals having from 1 to 6 carbon atoms inclusive in linear and branched chains, cycloalkyl having from 3 to 7 carbon atoms, and radicals of the formula : ##EQU10## wherein : A is selected from the group consisting of a single bond and saturated and unsaturated acyclic hydrocarbon radicals having from 1 to 6 carbon atoms inclusive in linear and branched chains, and Ar and R", which are the same or different, are selected from the group consisting of unsubstituted phenyl or phenyl substituted by one or more radicals selected from the group consisting of linear and branched alkoxy having from 1 to 6 carbon atoms inclusive, methylenedioxy, ethylenedioxy and trimethylenedioxy ; and B. physiologically tolerable acid addition salts thereof.
Claim 2
Dependent Claim
220 words
A compound selected from the group consisting of : A. heterocyclic amides of the general formula I : ##SPC8## wherein: X is CH ; n is selected from 0 and 1, and R is selected from the group consisting of : ##EQU9## wherein : R 1 is selected from the group consisting of hydrogen and methyl, R 2 and R 3 joined together represent a polymethylenic chain of the formula -- (CH 2 ) p -- wherein p is an integer from 4 to 7 inclusive and R' is selected from the group consisting of saturated and unsaturated acyclic hydrocarbon radicals having from 1 to 6 carbon atoms inclusive in linear and branched chains, cycloalkyl having from 3 to 7 carbon atoms, and radicals of the formula : ##EQU10## wherein : A is selected from the group consisting of a single bond and saturated and unsaturated acyclic hydrocarbon radicals having from 1 to 6 carbon atoms inclusive in linear and branched chains, and Ar and R", which are the same or different, are selected from the group consisting of unsubstituted phenyl or phenyl substituted by one or more radicals selected from the group consisting of linear and branched alkoxy having from 1 to 6 carbon atoms inclusive, methylenedioxy, ethylenedioxy and trimethylenedioxy ; and B. physiologically tolerable acid addition salts thereof.
Claim 3
Dependent Claim
90 words
A compound of claim 1 which is selected from the group consisting of : A. heterocyclic amides of the general formula I" : ##SPC9## wherein : n has the meaning given in claim 1, and R' is selected from the group consisting of linear and branched saturated and unsaturated acyclic hydrocarbon radicals having from 1 to 6 carbon atoms inclusive, cyclohexyl, phenylalkyl wherein the alkyl moiety which is linear or branched has from 1 to 6 carbon atoms inclusive, and phenyloxyethyl ; and B. physiologically tolerable acid addition salts thereof.
Claim 4
Dependent Claim
10 words
A compound of claim 1 which is 2-(6-amino nicotinamidomethyl)-1-ethyl pyrrolidine:
Claim 5
Dependent Claim
10 words
A compound of claim 1 which is 2-(6-amino nicotinamidomethyl)-1-isobutyl pyrrolidine.
Claim 6
Dependent Claim
10 words
A compound of claim 1 which is 2-(6-amino nicotinamidomethyl)-1-allyl pyrrolidine.
Claim 7
Dependent Claim
10 words
A compound of claim 1 which is 2-(6-amino nicotinamidomethyl)-1-(3-phenylpropyl) pyrrolidine.
Claim 8
Dependent Claim
10 words
A compound of claim 1 which is 2-(6-amino nicotinamidomethyl)-1-(3-phenyl-2-propyl) pyrrolidine.
References Cited (Backward Citations)
US3105072A
Cited
US3108113A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-20 | 1980-01-19 | 1980-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-20 | 1984-01-19 | 1984-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-20 | 1988-01-19 | 1988-07-20 | $7700.00 | Window Closed / Lapsed |