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US3969503A
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Compositions and methods useful in rendering lithogenic mammalian bile non-lithogenic
Assignee: CHOLEX LABORATORIES INC A CORP OF NY
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Filing: 1975-10-02
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Granted: 1976-07-13
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Expires: 1995-10-02
Abstract
Abstract A method of rendering mammalian bile non-lithogenic which comprises administering to a mammal having lithogenic bile, a small but effective amount of a compound of the formula ##SPC1## Wherein each Y is hydrogen; each X is selected from the group consisting of hydroxy and acyloxy; and when taken together X and Y is oxo (O=); and R is hydroxy, acyloxy or alkoxy; and the pharmaceutically acceptable non-toxic salts thereof; in combination with a small but effective amount of a choloretic agent selected from the group consisting of dehydrocholic acid, glycocholic acid, florantyrone, and tocamphyl.
Inventors
- 👤 William H. Saltzman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 15:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/575
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
81 words
A composition for rendering lithogenic mammalian bile non-lithogenic which comprises, in combination: a. a small but effective amount of a compound of the formula ##SPC3## wherein each Y is hydrogen; each X is hydroxy or acyloxy; when taken together X and Y is oxo (O=); and R is hydroxy, acyloxy or alkoxy; and pharmaceutically acceptable salts thereof; and b. a small but effective amount of a choloretic agent selected from the group consisting of dehydrocholic acid, glycocholic acid, florantyrone and tocamphyl.
Claim 2
Dependent Claim
81 words
A composition for rendering lithogenic mammalian bile non-lithogenic which comprises, in combination: a. a small but effective amount of a compound of the formula ##SPC3## wherein each Y is hydrogen; each X is hydroxy or acyloxy; when taken together X and Y is oxo (O=); and R is hydroxy, acyloxy or alkoxy; and pharmaceutically acceptable salts thereof; and b. a small but effective amount of a choloretic agent selected from the group consisting of dehydrocholic acid, glycocholic acid, florantyrone and tocamphyl.
Claim 3
Dependent Claim
63 words
The method of rendering lithogenic mammalian bile non-lithogenic which comprises, administering to a mammal having lithogenic bile, a small but effective amount of a compound of the formula ##SPC4## wherein X, Y and R are as defined in claim 1; and a small but effective amount of a choloretic agent selected from the group consisting of dehydrocholic acid, glycocholic acid, florantyrone and tocamphyl.
Claim 4
Dependent Claim
14 words
The method of claim 2 wherein the compound is chenodeoxycholic acid or ursodeoxycholic acid.
Claim 5
Dependent Claim
13 words
The method of claim 2 wherein the choloretic agent is florantyrone or tocamphyl.
Claim 6
Dependent Claim
17 words
The method of claim 2 wherein the compound is chenodeoxycholic acid and the choloretic agent is tocamphyl.
Claim 7
Dependent Claim
17 words
The method of claim 2 wherein the compound is chenodeoxycholic acid and the choloretic agent is florantyrone.
References Cited (Backward Citations)
US3919266A
Cited
US3891681A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-13 | 1980-01-12 | 1980-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-13 | 1984-01-12 | 1984-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-13 | 1988-01-12 | 1988-07-13 | $7700.00 | Window Closed / Lapsed |