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US3963750A
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US
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Thiophene derivatives
Assignee: Beecham Group PLC
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Filing: 1974-07-23
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Granted: 1976-06-15
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Expires: 1994-07-23
Abstract
Abstract Compounds of the formula: ##SPC1## Wherein R 1 is NHR 5 or OR 5 where R 5 is a hydrogen atom or alkyl group of 1-6 carbon atoms; R 2 is a hydrogen atom or a CO.R 6 group where R 6 is an alkyl group of 1-6 carbon atoms; R 3 is a phenyl group substituted by 1 or 2 halogen atoms or methyl, trifluoromethyl or methoxyl groups; and R 4 is a hydrogen atom or an alkyl group of 1-6 carbon atoms or a phenyl group optionally substituted by 1 or 2 halogen atoms or methyl, trifluoromethyl or methoxyl groups; and salts thereof; have been found to possess valuable anti-inflammatory properties. The preparation and use of such compounds is described.
Inventors
- 👤 Alexander Crossan Goudie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:32
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
37 words
A compound of the formula (II): ##SPC4## or a pharmaceutically acceptable non-toxic salt thereof, wherein A 1 is NHA 3 wherein A 3 is hydrogen or alkyl of 1- 6 carbon atoms; and A 2 is fluorine.
Claim 2
Dependent Claim
37 words
A compound of the formula (II): ##SPC4## or a pharmaceutically acceptable non-toxic salt thereof, wherein A 1 is NHA 3 wherein A 3 is hydrogen or alkyl of 1- 6 carbon atoms; and A 2 is fluorine.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 wherein A 2 is 4-fluorine.
Claim 4
Dependent Claim
13 words
A compound according to claim 2 wherein A 1 is amino or methylamine.
Claim 5
Dependent Claim
1 words
2-Amino-5-(4-fluorophenyl)-3-thiophenecarboxamide.
Claim 6
Dependent Claim
1 words
2-Amino-5-(4-fluorophenyl)-3-thiophenecarboxamide.
References Cited (Backward Citations)
US3832354A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-15 | 1979-12-15 | 1980-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-15 | 1983-12-15 | 1984-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-15 | 1987-12-15 | 1988-06-15 | $7700.00 | Window Closed / Lapsed |