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US3962240A
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Process for the preparation of furo(3,4-e)-as-triazines
Assignee: Sandoz Inc
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Filing: 1975-05-08
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Granted: 1976-06-08
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Expires: 1995-05-08
Abstract
Abstract 5,5,7,7-tetramethyl-3-substituted or unsubstituted-phenylfuro[3,4-e]-as-triazines, e.g., 5,7-dihydro-5,5,7,7-tetramethyl-3-(m-nitrophenyl)furo[3,4-e]-as-triazine, are prepared by reacting a 2,2,5,5-tetramethyl-3,4(2H,5H)furandione with substituted or unsubstituted benzimidic acid hydrazide under an inert atmosphere in the presence of an inert organic solvent and are useful as sleep inducers and minor tranquilizers.
Inventors
- 👤 Gregory Benjamin Bennett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 15:37
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
149 words
A process for preparing a compound of the formula ##SPC4## which comprises treating a compound of the formula ##SPC5## with a compound of the formula ##SPC6## under an inert atmosphere in the presence of an inert organic solvent, where R 1 and R 2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, and provided that i. when one of R 1 and R 2 represents nitro, the other is other than nitro or trifluoromethyl; ii. when R 1 and R 2 represent trifluoromethyl, they are on other than adjacent carbon atoms, iii. when R 1 and R 2 represent t-butyl, they are on other than adjacent carbon atoms, and iv. when one of R 1 and R 2 is trifluoromethyl and the other is t-butyl, they are on other than adjacent carbon atoms.
Claim 2
Dependent Claim
149 words
A process for preparing a compound of the formula ##SPC4## which comprises treating a compound of the formula ##SPC5## with a compound of the formula ##SPC6## under an inert atmosphere in the presence of an inert organic solvent, where R 1 and R 2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, and provided that i. when one of R 1 and R 2 represents nitro, the other is other than nitro or trifluoromethyl; ii. when R 1 and R 2 represent trifluoromethyl, they are on other than adjacent carbon atoms, iii. when R 1 and R 2 represent t-butyl, they are on other than adjacent carbon atoms, and iv. when one of R 1 and R 2 is trifluoromethyl and the other is t-butyl, they are on other than adjacent carbon atoms.
Claim 3
Dependent Claim
19 words
A process according to claim 1 which is carried out at a temperature of from about 50° to 150°C.
Claim 4
Dependent Claim
19 words
A process according to claim 1 which is carried out at a temperature of from about 70° to 110°C.
Claim 5
Dependent Claim
16 words
A process according to claim 3 in which the inert organic solvent is a lower alkanol.
Claim 6
Dependent Claim
17 words
A process according to claim 2 in which the reaction is run from 1 to 42 hours.
Claim 7
Dependent Claim
14 words
A process according to claim 3 which is carried out under a nitrogen atmosphere.
Claim 8
Dependent Claim
28 words
A process according to claim 1 which is carried out under an inert atmosphere at a temperature of 70° to 110°C. in the presence of a lower alkanol.
Claim 9
Dependent Claim
46 words
A process for preparing a compound of the formula ##SPC7## which comprises treating a compound of the formula ##SPC8## with a compound of the formula ##SPC9## under an inert atmosphere and in the presence of an inert organic solvent at a temperature of 50° to 150°C.
Claim 10
Dependent Claim
46 words
A process for preparing a compound of the formula ##SPC7## which comprises treating a compound of the formula ##SPC8## with a compound of the formula ##SPC9## under an inert atmosphere and in the presence of an inert organic solvent at a temperature of 50° to 150°C.
Claim 11
Dependent Claim
17 words
A process according to claim 8 which is carried out at a temperature of 70° to 110°C.
Claim 12
Dependent Claim
16 words
A process according to claim 9 in which the inert organic solvent is a lower alkanol.
References Cited (Backward Citations)
US3697518A
Cited
US3772276A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-08 | 1979-12-08 | 1980-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-08 | 1983-12-08 | 1984-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-08 | 1987-12-08 | 1988-06-08 | $7700.00 | Window Closed / Lapsed |