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US3961004A
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US
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Method of tabletting using gluconolactone as the direct compression diluent
Assignee: Auburn Research Foundation
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Filing: 1974-04-11
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Granted: 1976-06-01
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Expires: 1994-04-11
Abstract
Abstract A method for producing pharmaceutical tablets, confectionary tablets or lozenges using gluconolactone in its delta or gamma lactone form as the direct compression diluent. The ingredients are mixed with gluconolactone, and then compressed directly on a tablet press without any modification in the particle size after mixing.
Inventors
- 👤 Syed Shahid Nasir
- 👤 Leon Otto Wilken, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:01
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2018
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
71 words
In a method for producing a tablet selected from the group consisting of pharmaceutical, confectionary, and lozenge by the direct compression method consisting essentially of mixing the ingredients with a compression diluent and compressing said ingredients and diluent directly on a tablet press without any modification in the particle size after mixing wherein the improvement is using gluconolactone in an amount sufficient to act as the direct compression diluent by itself.
Claim 2
Dependent Claim
71 words
In a method for producing a tablet selected from the group consisting of pharmaceutical, confectionary, and lozenge by the direct compression method consisting essentially of mixing the ingredients with a compression diluent and compressing said ingredients and diluent directly on a tablet press without any modification in the particle size after mixing wherein the improvement is using gluconolactone in an amount sufficient to act as the direct compression diluent by itself.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the gluconolactone is selected from the group consisting of D-gluconic acid delta lactone, D-gluconic acid gamma lactone.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein the gluconolactone is used in its commercially available form.
Claim 5
Dependent Claim
23 words
The method of claim 1 wherein the gluconolactone is present in an amount up to about 89% by weight of the total composition.
Claim 6
Dependent Claim
25 words
The method of claim 1 wherein the ingredients contain an active ingredient in an amount of 0.00% to 58% by weight of the total composition.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein the gluconolactone is of a mesh size of 80/100-mesh.
Claim 8
Dependent Claim
18 words
The method of claim 1 wherein the diluent and ingredients are compressible with particle size finer than 5-mesh.
Claim 9
Dependent Claim
16 words
The method of claim 1 wherein the mesh size of the gluconolactone is less than 30-mesh.
Claim 10
Dependent Claim
30 words
The method of claim 1 wherein there is contained at least 11% of at least one member selected from the group consisting of binders, lubricants, flavoring material and active ingredient.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein the gluconolactone is milled prior to mixing.
Claim 12
Dependent Claim
14 words
The method of claim 1 wherein the gluconolactone has a moisture content of 0.5%.
References Cited (Backward Citations)
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US3308217A
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US3619292A
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US3639168A
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US3642535A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |