US3960894A
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9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
Assignee: Sandoz AG
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Filing: 1974-07-26
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Granted: 1976-06-01
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Expires: 1994-07-26
Abstract
Abstract The present invention concerns a novel process for the production of known benzocycloheptathiophene derivatives of the formula: ##SPC1## Wherein R 1 is hydrogen, chlorine, bromine or alkoxy, and R 2 is alkyl. The compounds are useful as specific histaminolytics for use in the treatment of allergic conditions.
Inventors
- 👤 Jean-Pierre Bourquin
- 👤 Gustav Schwarb
- 👤 Erwin Waldvogel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:01
CPC Classifications
C; C07; C07D; C07D409/00; C07D409/02; C07D409/04; C07D333/00; C07D333/50; C07D333/78
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
49 words
A compound of the formula: ##SPC11## wherein R 1 is in the 6 or 7 position of the benzocycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, R 3 is alkyl of 1 to 4 carbon atoms, and X is chlorine or bromine.
Claim 2
Dependent Claim
49 words
A compound of the formula: ##SPC11## wherein R 1 is in the 6 or 7 position of the benzocycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, R 3 is alkyl of 1 to 4 carbon atoms, and X is chlorine or bromine.
Claim 3
Dependent Claim
9 words
The compound of claim 1, which is 9-bromo-9,10-dihydro-10-methoxy-4H-benzo[ 4,5]cyclohepta[1,2-b]thiophen-4-one.
Claim 4
Dependent Claim
9 words
The compound of claim 1 which is 9-bromo-6-chloro-9,10-dihydro-10-methoxy-4H-benzo[4,5]cyclohepta[ 1,2-b]thiophen-4-one.
Claim 5
Dependent Claim
9 words
The compound of claim 1 which is 9-bromo-7-chloro-9,10-dihydro-10-methoxy-4H-benzo[4,5]cyclohepta[ 1,2-b]thiophen-4-one.
Claim 6
Dependent Claim
9 words
The compound of claim 1 which is 6,9-dibromo-9,10-dihydro-10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
Claim 7
Dependent Claim
9 words
The compound of claim 1 which is 9-bromo-9,10-dihydro-7,10-dimethoxy-4H-benzo[4,5]cyclohepta[ 1,2-b]thiophen-4-one.
Claim 8
Dependent Claim
8 words
The compound of claim 1 which is 9-chloro-9,10-dihydro-10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one.
Claim 9
Dependent Claim
8 words
The compound of claim 1 which is 9-bromo-10-butoxy-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one.
Claim 10
Dependent Claim
8 words
The compound of claim 1 which is 9-bromo-10-ethoxy-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one.
Claim 11
Dependent Claim
49 words
A process for the production of a compound of the formula ##SPC12## which comprises reacting a compound of the formula ##SPC13## with a compound of the formula R.sub.3 OH in the presence of silver nitrate, wherein R 1 , R 3 and X are as defined in claim 1.
Claim 12
Dependent Claim
100 words
A process for the production of a compound of the formula: ##SPC14## wherein R 1 is in the 6 or 7 position of the benzocycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, and R 3 is alkyl of 1 to 4 carbon atoms, and X is chlorine or bromine, which comprises reacting a compound of the formula: ##SPC15## wherein R 1 and X are as defined, R 1 being in the 6 or 7 position of the benzocycloheptathiophene nucleus, with a compound of the formula: R.sub.3 OH wherein R 3 is as defined.
Claim 13
Dependent Claim
100 words
A process for the production of a compound of the formula: ##SPC14## wherein R 1 is in the 6 or 7 position of the benzocycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, and R 3 is alkyl of 1 to 4 carbon atoms, and X is chlorine or bromine, which comprises reacting a compound of the formula: ##SPC15## wherein R 1 and X are as defined, R 1 being in the 6 or 7 position of the benzocycloheptathiophene nucleus, with a compound of the formula: R.sub.3 OH wherein R 3 is as defined.
References Cited (Backward Citations)
GB1169755A
Cited
US3853915A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |