US3957791A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxyalkyl-piperazino-quinoline nitrates
Assignee: Sandoz Inc
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Filing: 1974-09-09
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Granted: 1976-05-18
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Expires: 1994-09-09
Abstract
Abstract Disclosed are compounds of the class of quinolines substituted at the 2-, 3- or 4- position by an amino function bearing a hydroxyalkyl nitrate moiety, e.g. 4-(2-hydroxyethylpiperazino)-quinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as hypotensive and anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive and anti-anginal agents.
Inventors
- 👤 William R. Simpson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 14:53
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/38; C07D215/42; C07D215/46
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
90 words
A compound of the formula: ##SPC7## wherein z is 1 to 4, and each of Y, Y', Y" and Y'" is hydrogen, fluoro, chloro, bromo, alkoxy of 1 to 3 carbon atoms or alkyl of 1 to 3 carbon atoms, or Y and Y' together form methylenedioxy, provided that at least 2 of Y, Y', Y" and Y'" are hydrogen and further provided that when one of Y, Y', Y" and Y'" is fluoro, chloro or bromo, then the others are hydrogen, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
90 words
A compound of the formula: ##SPC7## wherein z is 1 to 4, and each of Y, Y', Y" and Y'" is hydrogen, fluoro, chloro, bromo, alkoxy of 1 to 3 carbon atoms or alkyl of 1 to 3 carbon atoms, or Y and Y' together form methylenedioxy, provided that at least 2 of Y, Y', Y" and Y'" are hydrogen and further provided that when one of Y, Y', Y" and Y'" is fluoro, chloro or bromo, then the others are hydrogen, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
22 words
A compound of claim 1 of the formula: ##SPC8## wherein z, Y, Y', Y" and Y'" are as defined in claim 1.
Claim 4
Dependent Claim
20 words
The compound of claim 2 in which z is 1 and each of Y, Y', Y" and Y'" is hydrogen.
Claim 5
Dependent Claim
22 words
A compound of claim 1 of the formula: ##SPC9## wherein z, Y, Y', Y" and Y'" are as defined in claim 1.
Claim 6
Dependent Claim
20 words
The compound of claim 4 in which z is 1 and each of Y, Y', Y" and Y'" is hydrogen.
Claim 7
Dependent Claim
23 words
The compound of claim 4 in which z is 1, Y and Y' are each methoxy and Y" and Y'" are each hydrogen.
References Cited (Backward Citations)
US3173918A
Cited
US3856796A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-18 | 1979-11-17 | 1980-05-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-18 | 1983-11-17 | 1984-05-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-18 | 1987-11-17 | 1988-05-18 | $7700.00 | Window Closed / Lapsed |