US3856796A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxyalkyl-substituted-amino-quinolines and nitrates thereof
Assignee: Sandoz AG
•
Filing: 1972-09-25
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Granted: 1974-12-24
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Expires: 1992-09-25
Abstract
Abstract Disclosed are compounds of the class of quinolines substituted at the 2-, 3- or 4- position by an amino function bearing a hydroxyalkyl nitrate moiety, e.g. 4-(2-hydroxyethylpiperazino)quinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as hypotensive and anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive and anti-anginal agents.
Inventors
- 👤 W Simpson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 20:19
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/38; C07D215/42
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
8 words
A compound of claim 1 having the formula:
Claim 4
Dependent Claim
10 words
A compound of claim 2 in which R1 is hydrogen.
Claim 5
Dependent Claim
10 words
A compound of claim 3 in which R is -CH2(-CH2)n-ONO2.
Claim 6
Dependent Claim
10 words
A compound of claim 3 in which R is -CH2(-CH2)n-N(-CH2(-CH2)y-ONO2)2.
Claim 7
Dependent Claim
23 words
The compound of claim 4 in which n is 4, Y and Y'' are each methoxy and Y'''' and Y'''''' are each hydrogen.
Claim 8
Dependent Claim
23 words
The compound of claim 5 in which n is 2, y is 1 and each of Y, Y'', Y'''' and Y'''''' is hydrogen.
Claim 9
Dependent Claim
9 words
A compound of claim 3 in which R is
Claim 10
Dependent Claim
10 words
A compound of claim 8 in which Ro is -(CH2)y-ONO2.
Claim 11
Dependent Claim
22 words
The compound of claim 9 in which n and y are 1 and each of Y, Y'', Y'''' and Y'''''' is hydrogen.
Claim 12
Dependent Claim
8 words
A compound of claim 1 having the formula:
Claim 13
Dependent Claim
10 words
A compound of claim 11 in which R1 is hydrogen.
Claim 14
Dependent Claim
10 words
A compound of claim 12 in which R is -CH2(-CH2)n-ONO2.
Claim 15
Dependent Claim
10 words
A compound of claim 12 in which R is -CH2(-CH2)n-N(-CH2(-CH2)y-ONO2.
Claim 16
Dependent Claim
16 words
The compound of claim 13 in which n is 4, Y and Y'' are each methoxy.
Claim 17
Dependent Claim
23 words
The compound of claim 14 in which n is 2, y is 1 and each of Y, Y'', Y'''' and Y'''''' is hydrogen.
Claim 18
Dependent Claim
9 words
A compound of claim 12 in which R is
Claim 19
Dependent Claim
10 words
A compound of claim 17 in which Ro is -(CH2)y-ONO2.
Claim 20
Dependent Claim
22 words
The compound of claim 18 in which n and y are 1 and each of Y, Y'', Y'''' and Y'''''' are hydrogen.
Claim 21
Dependent Claim
23 words
The compound of claim 14 in which n is 2, y is 1, and each of Y, Y'', Y'''' and Y'''''' is hydrogen.
Claim 22
Dependent Claim
22 words
The compound of claim 13 in which n is 4, Y'' is methoxy and each of Y, Y'''' and Y'''''' is hydrogen.
Claim 23
Dependent Claim
8 words
A compound of claim 1 having the formula:
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-23 | 1978-06-24 | 1978-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-23 | 1982-06-24 | 1982-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-23 | 1986-06-24 | 1986-12-24 | $7700.00 | Window Closed / Lapsed |