Patent US3956259A successfully refreshed from Google Patents.
US3956259A
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Fractionation of blood using block copolymer of ethylene oxide and polyoxypropylene polymer to recover fraction suitable for organ perfusate
Assignee: Baxter International Inc
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Filing: 1974-06-06
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Granted: 1976-05-11
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Expires: 1994-06-06
Abstract
Abstract A method of fractionating coagulation factor-depleted blood serum or plasma by selective precipitation with block copolymers of ethylene oxide and polyoxypropylene polymer to provide immunoglobulin preparations, albumin-containing fractions and organ perfusates.
Inventors
- 👤 Luis A. Garcia
- 👤 Guido A. Ordonez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:09
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
159 words
The process of preparing a blood fraction suitable for use as an organ perfusate from coagulation factor-depleted blood serum and plasma comprising selective precipitation by admixing with from about 2% to about 12% of a compound of the formula ##EQU2## wherein a and c are integers such that the hydrophile portion represented by (CH 2 CH 2 O) constitutes at least about 50% of the molecule and b is an integer such that the hydrophobic portion represented by ##EQU3## has a molecular weight of at least about 950 at a pH from about 4 to 5, separating the resulting precipitate from the supernatant and then adjusting the concentration of said copolymer in said supernatant to from about 14% to about 24% and adjusting to a pH of from about 4 to about 5 with acetate buffer at a temperature of from about 0° C to about 10° C to provide a precipitate for reconstitution to the desired organ perfusate.
Claim 2
Dependent Claim
159 words
The process of preparing a blood fraction suitable for use as an organ perfusate from coagulation factor-depleted blood serum and plasma comprising selective precipitation by admixing with from about 2% to about 12% of a compound of the formula ##EQU2## wherein a and c are integers such that the hydrophile portion represented by (CH 2 CH 2 O) constitutes at least about 50% of the molecule and b is an integer such that the hydrophobic portion represented by ##EQU3## has a molecular weight of at least about 950 at a pH from about 4 to 5, separating the resulting precipitate from the supernatant and then adjusting the concentration of said copolymer in said supernatant to from about 14% to about 24% and adjusting to a pH of from about 4 to about 5 with acetate buffer at a temperature of from about 0° C to about 10° C to provide a precipitate for reconstitution to the desired organ perfusate.
Claim 3
Dependent Claim
32 words
The process of claim 1 in which the block copolymer contains about 80% of polyoxyethylene hydrophilic units in the molecule and the polyoxypropylene hydrophobic base has a molecular weight of about 950.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-11 | 1979-11-10 | 1980-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-11 | 1983-11-10 | 1984-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-11 | 1987-11-10 | 1988-05-11 | $7700.00 | Window Closed / Lapsed |