Patent US3955559A successfully refreshed from Google Patents.
US3955559A
Expired / Lapsed
US
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Method of cytological diagnosis of precancer conditions and cancer
Assignee: Individual
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Filing: 1974-08-13
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Granted: 1976-05-11
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Expires: 1994-08-13
Abstract
Abstract The method for cytological diagnosis for precancer conditions and cancer which consists in the fact that the coefficient of the cell size is calculated for each cell in the cytological sample from the area of the nucleus, and the area of the cytoplasm, and where the values exceeding 0.5 are selected and used to determine the mean value which serves as a criterion for diagnosing the disease.
Inventors
- 👤 Velta Mikelevna Bramberga
- 👤 Arkady Yakovlevich Khesin
- 👤 Teodor Arvidovich Grendze
- 👤 Mark Naumovich Libenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:08
CPC Classifications
G; G01; G01N; G01N15/00; G01N15/10; G01N15/14; G01N15/1468
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
204 words
A method for the cytological diagnosis of cancer and precancer conditions, comprising taking a cytological preparation from a suspected patient; measuring the area of the nucleus and the area of the cytoplasm in each cell under examination; determining the coefficient of the cell size η(c) for each said cell according to the relationship η(c) = ν + cS.sub.1 =(S.sub.1 /S.sub.2) + cS.sub.1 where ν = the nucleus to cytoplasm ratio S 1 = the area of the nucleus S 2 = the area of the cytoplasm C = a constant coefficient of from 0 to 0.025; selecting from the thus obtained multitude of cell size coefficients, the values exceeding 0.5; and determining the mean value for the selected values of the cell size coefficients, whereby if said mean value of the cell size coefficient falls within the range of from 0.0 to 0.6, the preparation is considered to belong to a healthy person; if the mean value of the cell size coefficient is from 0.6 to 0.8, the preparation is considered to belong to a patient with a precancer condition; and, finally, if the mean value of the cell size coefficient exceeds 0.9, the preparation is diagnosed as belonging to a patient with cancer.
Claim 2
Independent Claim
204 words
A method for the cytological diagnosis of cancer and precancer conditions, comprising taking a cytological preparation from a suspected patient; measuring the area of the nucleus and the area of the cytoplasm in each cell under examination; determining the coefficient of the cell size η(c) for each said cell according to the relationship η(c) = ν + cS.sub.1 =(S.sub.1 /S.sub.2) + cS.sub.1 where ν = the nucleus to cytoplasm ratio S 1 = the area of the nucleus S 2 = the area of the cytoplasm C = a constant coefficient of from 0 to 0.025; selecting from the thus obtained multitude of cell size coefficients, the values exceeding 0.5; and determining the mean value for the selected values of the cell size coefficients, whereby if said mean value of the cell size coefficient falls within the range of from 0.0 to 0.6, the preparation is considered to belong to a healthy person; if the mean value of the cell size coefficient is from 0.6 to 0.8, the preparation is considered to belong to a patient with a precancer condition; and, finally, if the mean value of the cell size coefficient exceeds 0.9, the preparation is diagnosed as belonging to a patient with cancer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-11 | 1979-11-10 | 1980-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-11 | 1983-11-10 | 1984-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-11 | 1987-11-10 | 1988-05-11 | $7700.00 | Window Closed / Lapsed |