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US3953601A
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Dibenzothiophene derivatives as serum lipid lowering agents
Assignee: AstraZeneca AB
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Filing: 1974-02-28
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Granted: 1976-04-27
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Expires: 1994-02-28
Abstract
Abstract A compound of the general formula ##SPC1## And pharmaceutically acceptable salts thereof, in which formula R 0 is H, F, Cl, Br or OCH 3 ; R 1 and R 2 are the same or different and selected from the group consisting of H and alkyl groups having 1-3 carbon atoms; R 3 is H or an alkyl group having 1-3 carbon atoms; R 0 and the side-chain containing the radicals R 1 , R 2 and R 3 being placed on the same or different benzene ring. Pharmaceutical preparations containing these compounds are useful in a method for lowering the serum lipid concentration in mammals, including man. These same preparations are also useful for the combined lowering of serum cholesterol and triglyceride concentrations.
Inventors
- 👤 Ulf Goran Bondesson
- 👤 Salo Schmul Gronowitz
- 👤 Nils Erik Stjernstrom
- 👤 Tage Rolf Gunnar Svensson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 12:32
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/50; C07D333/76
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
119 words
A method for the treatment of excessive serum lipid concentrations in mammals comprising administering orally to a mammal in need thereof a therapeutically effective amount of a dibenzothiophene derivative having the formula ##SPC6## in which formula R 0 is selected from the group consisting of H, F, Cl, Br and OCH 3 ; R 1 and R 2 are the same or different and are selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 3 is selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 0 and the side chain containing the radicals R 1 , R 2 and R 3 being on the same or different benzene ring.
Claim 2
Independent Claim
119 words
A method for the treatment of excessive serum lipid concentrations in mammals comprising administering orally to a mammal in need thereof a therapeutically effective amount of a dibenzothiophene derivative having the formula ##SPC6## in which formula R 0 is selected from the group consisting of H, F, Cl, Br and OCH 3 ; R 1 and R 2 are the same or different and are selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 3 is selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 0 and the side chain containing the radicals R 1 , R 2 and R 3 being on the same or different benzene ring.
Claim 3
Dependent Claim
41 words
The method according to claim 1 comprising administering orally a dibenzothiophene derivative having the formula ##SPC7## in which formula the groups R 0 , R 1 , R 2 and R 3 have the same meanings as defined in claim 1.
Claim 4
Dependent Claim
46 words
The method according to claim 1 comprising administering orally the dibenzothiophene derivative of formula I in which formula R 0 represents hydrogen; R 1 and R 2 are the same and represent methyl; and R 3 is selected from the group consisting of hydrogen and ethyl.
Claim 5
Dependent Claim
11 words
The method according to claim 1, comprising administering orally 2-(4-dibenzothiophenoxy)-2-methylpropionic acid.
Claim 6
Dependent Claim
11 words
The method according to claim 1 comprising administering orally ethyl 2-(4-dibenzothiophenoxy)-2-methylpropionate.
Claim 7
Dependent Claim
122 words
A composition for the treatment of excessive serum lipid concentrations in mammals comprising as an active ingredient a therapeutically effective amount of a dibenzothiophene derivative having the formula ##SPC8## in which formula R 0 is selected from the group consisting of H, F, Cl, Br and OCH 3 ; R 1 and R 2 are the same or different and are selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 3 is selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 0 and the side chain containing the radicals R 1 , R 2 and R 3 , being on the same or different benzene ring; in combination with a pharmaceutical carrier.
Claim 8
Dependent Claim
122 words
A composition for the treatment of excessive serum lipid concentrations in mammals comprising as an active ingredient a therapeutically effective amount of a dibenzothiophene derivative having the formula ##SPC8## in which formula R 0 is selected from the group consisting of H, F, Cl, Br and OCH 3 ; R 1 and R 2 are the same or different and are selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 3 is selected from the group consisting of H and alkyl having 1-3 carbon atoms; R 0 and the side chain containing the radicals R 1 , R 2 and R 3 , being on the same or different benzene ring; in combination with a pharmaceutical carrier.
Claim 9
Dependent Claim
43 words
The composition according to claim 6, comprising a therapeutically effective amount of a dibenzothiophene derivative having the formula ##SPC9## in which formula the groups R 0 , R 1 R 2 and R 3 have the same meanings as defined in claim 6.
Claim 10
Dependent Claim
49 words
The composition according to claim 6, comprising a therapeutically effective amount of the dibenzothiophene derivative of formula I, in which formula R 0 represents hydrogen; R 1 and R 2 are the same and represent methyl; and R 3 is selected from the group consisting of hydrogen and ethyl.
Claim 11
Dependent Claim
14 words
The composition according to claim 6, comprising a therapeutically effective amount of 2-(4-dibenzothiophenoxy)-2-methylpropionic acid.
Claim 12
Dependent Claim
14 words
The composition according to claim 6 comprising a therapeutically effective amount of ethyl 2-(4-dibenzothiophenoxy)-2-methylpropionate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-27 | 1979-10-27 | 1980-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-27 | 1983-10-27 | 1984-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-27 | 1987-10-27 | 1988-04-27 | $7700.00 | Window Closed / Lapsed |