US3953501A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Triiodoisophthalic acid monoamino acid amides
Assignee: Bayer Pharma AG
•
Filing: 1973-02-09
•
Granted: 1976-04-27
•
Expires: 1993-02-09
Abstract
Abstract New amino acid derivative of acylamino-5-alkylcarbamoyl-2,4,6-triiodobenzoic acids are described together with processes for their preparation and use and novel intermediates useful in preparing these compounds. The compounds are valuable radiopaque agents useful as X-ray contrast media.
Inventors
- 👤 Erich Klieger
- 👤 Wolfgang Beich
- 👤 Eberhard Schroder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:50
CPC Classifications
C; C07; C07C; C07C237/00; C07C237/28; C07C237/36; C07C237/46; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
59 words
A triiodoisophthalic acid monoamino acid amide of the formula ##SPC6## wherein ##EQU11## is divalent amino lower alkanoyl derived from a naturally occurring amino acid; R is alkyl, hydroxyalkyl or alkoxyalkyl of 1-6 carbon atoms; R 1 and R 2 are each hydrogen, alkyl of 1-6 carbon atoms or hydroxyalkyl of 2-6 carbon atoms and the physiologically acceptable salts thereof.
Claim 2
Dependent Claim
59 words
A triiodoisophthalic acid monoamino acid amide of the formula ##SPC6## wherein ##EQU11## is divalent amino lower alkanoyl derived from a naturally occurring amino acid; R is alkyl, hydroxyalkyl or alkoxyalkyl of 1-6 carbon atoms; R 1 and R 2 are each hydrogen, alkyl of 1-6 carbon atoms or hydroxyalkyl of 2-6 carbon atoms and the physiologically acceptable salts thereof.
Claim 3
Dependent Claim
19 words
A compound according to claim 1 wherein said amino acid is a monoaminomonocarboxylic acid or a heterocyclic amino acid.
Claim 4
Dependent Claim
15 words
A claim according to claim 1 wherein one of R 1 R 2 is hydrogen.
Claim 5
Dependent Claim
22 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-glycine methylamide; N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-glycine amide; N-(3-carboxy-5-valeroylamino-2,4,6-triiodobenzoyl)-glycine methylamide; N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-glycine ethanolamide; N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-glycine dimethylamide;
Claim 6
Dependent Claim
17 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-sarcosine methylamide; and N-(3-carboxy-5-methoxyacetamido-2,4,6-triiodobenzoyl)-sarcosine methylamide.
Claim 7
Dependent Claim
17 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-DL-serine methylamide; and N-(3-carboxy-5-methoxyacetamido-2,4,6-triiodobenzoyl)-DL-serine methylamide.
Claim 8
Dependent Claim
17 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-methoxyacetamido-2,4,6-triiodobenzoyl)-DL-valine methylamide and N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-DL-valine methylamide.
Claim 9
Dependent Claim
21 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-DL-alanine methylamide; N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-β-alanine methylamide; N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-N-phenylβ-alanine methylamide; and N-(3-carboxy-5-methoxyacetamido-2,4,6-triiodobenzoyl)-DL-alanine methylamide.
Claim 10
Dependent Claim
19 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-L-phenylalanine methylamide; N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-L-proline methylamide; and N-(3-carboxy-5-methoxyacetamido-2,4,6-triiodobenzoyl)-L-phenylalanine methylamide.
Claim 11
Dependent Claim
19 words
A compound according to claim 1 selected from the group consisting of N-(3-carboxy-5-acetamido-2,4,6-triiodobenzoyl)-DL-α-aminobutyric acid methylamide and N-(3-carboxy-5-methoxyacetamido-2,4,6-triiodobenzoyl)-DL-α-aminobutyric acid methylamide.
Claim 12
Dependent Claim
11 words
A compound according to claim 1, wherein R 3 is hydrogen.
References Cited (Backward Citations)
CA616717A
Cited
GB867880A
Cited
US3009952A
Cited
US3102880A
Cited
US3145197A
Cited
US3453322A
Cited
US3622616A
Cited
US3701771A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-27 | 1979-10-27 | 1980-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-27 | 1983-10-27 | 1984-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-27 | 1987-10-27 | 1988-04-27 | $7700.00 | Window Closed / Lapsed |