US3953431A
Expired / Lapsed
US
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Derivatives of digoxigenin
Assignee: Becton Dickinson and Co
•
Filing: 1973-09-28
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Granted: 1976-04-27
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Expires: 1993-09-28
Abstract
Abstract Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1## Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amnio acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine.
Inventors
- 👤 Herman Rutner
- 👤 Raul Rapun
- 👤 Nathan Lewin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 15:21
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/04; C07H13/06; C07J; C07J19/00; A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
58 words
A composition of matter comprising a compound having the following structural formula: ##SPC6## wherein R' is selected from the group consisting of --OH and OCOCH 3 ; B is selected from the group consisting of succinyl, maleyl, fumaryl and o-phthaloyl; and X is selected from the group consisting of --OH and OM wherein M is an alkali metal.
Claim 2
Dependent Claim
58 words
A composition of matter comprising a compound having the following structural formula: ##SPC6## wherein R' is selected from the group consisting of --OH and OCOCH 3 ; B is selected from the group consisting of succinyl, maleyl, fumaryl and o-phthaloyl; and X is selected from the group consisting of --OH and OM wherein M is an alkali metal.
Claim 3
Dependent Claim
9 words
The compound of claim 1 wherein B is succinyl.
Claim 4
Dependent Claim
9 words
The compound of claim 2 wherein X is OH.
Claim 5
Dependent Claim
9 words
The compound of claim 3 wherein R' is --OH.
Claim 6
Dependent Claim
11 words
The compound of claim 3 wherein R' is --OCOCH 3 .
Claim 7
Dependent Claim
9 words
The compound of claim 2 wherein X is OM.
Claim 8
Dependent Claim
9 words
The compound of claim 6 wherein M is sodium.
Claim 9
Dependent Claim
9 words
The compound of claim 7 wherein R' is --OH.
Claim 10
Dependent Claim
11 words
The compound of claim 7 wherein R' is --OCOCH 3 .
References Cited (Backward Citations)
US3655643A
Cited
US3855208A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-27 | 1979-10-27 | 1980-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-27 | 1983-10-27 | 1984-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-27 | 1987-10-27 | 1988-04-27 | $7700.00 | Window Closed / Lapsed |