Patent US3951999A successfully refreshed from Google Patents.
US3951999A
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Anti-inflammatory 1,2-benzisoxazole derivatives
Assignee: Lilly Industries Ltd
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Filing: 1974-10-16
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Granted: 1976-04-20
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Expires: 1994-10-16
Abstract
Abstract 3-Phenyl substituted 1,2-benzisoxazole acetic and propionic acid derivatives with anti-inflammatory activity.
Inventors
- 👤 John Christopher Saunders
- 👤 William Robert Nigel Williamson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:07
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/52; C07D263/54; C07D263/56; C07D263/57; A; A61; A61P; A61P29/00; C07C; C07C45/00; C07C45/45; C07C45/46; C07D261/00; C07D261/20
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
114 words
A 1,2-benzisoxazole derivative of formula I: ##SPC10## wherein R 1 represents one or two substituents substituted in any of the available positions in the benzene ring selected from the class consisting of hydrogen, chlorine, bromine, C 1 -4 alkyl, C 1 -C 4 alkoxy, nitro, and trifluoromethyl, and R 2 is a substituent at the 5-, 6-, or 7- position of the 1,2-benzisoxazole nucleus and is one of the following: carboxy C 1 -4 alkyl, --CH(R 3 ).COOH, --CH 2 .COOR 3 and --CH(R 3 ).COOR 3 , where R 3 is C 1 -4 alkyl; and pharmaceutically acceptable salts thereof when R 2 is carboxy C 1 -4 alkyl or CH(R 3 ).COOH.
Claim 2
Dependent Claim
114 words
A 1,2-benzisoxazole derivative of formula I: ##SPC10## wherein R 1 represents one or two substituents substituted in any of the available positions in the benzene ring selected from the class consisting of hydrogen, chlorine, bromine, C 1 -4 alkyl, C 1 -C 4 alkoxy, nitro, and trifluoromethyl, and R 2 is a substituent at the 5-, 6-, or 7- position of the 1,2-benzisoxazole nucleus and is one of the following: carboxy C 1 -4 alkyl, --CH(R 3 ).COOH, --CH 2 .COOR 3 and --CH(R 3 ).COOR 3 , where R 3 is C 1 -4 alkyl; and pharmaceutically acceptable salts thereof when R 2 is carboxy C 1 -4 alkyl or CH(R 3 ).COOH.
Claim 3
Dependent Claim
16 words
A 1,2-benzisoxazole as claimed in claim 1 wherein R 2 is --CH 2 COOH or --CH(Me)COOH.
Claim 4
Dependent Claim
14 words
A 1,2-benzisoxazole as claimed in claim 2, wherein R 1 is a parahalo substituent.
Claim 5
Dependent Claim
3 words
α-Methyl-3--p-chlorophenyl-1,2-benzisoxazol-7-yl acetic acid.
Claim 6
Dependent Claim
3 words
α-Methyl-3--p-chlorophenyl-1,2-benzisoxazol-7-yl acetic acid.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-20 | 1979-10-20 | 1980-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-20 | 1983-10-20 | 1984-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-20 | 1987-10-20 | 1988-04-20 | $7700.00 | Window Closed / Lapsed |