Aminobenzyl-amides and salts thereof

Abstract

Abstract Compounds of the formula WHEREIN R1is hydrogen or aliphatic or aromatic carboxylic acyl, R2 is hydrogen, chlorine or bromine, R3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or R6 -CH2-N ANGLE R7 where R6 and R7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, and R4 and R5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy(cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS ANTI-ULCERGENICS, SECRETOLYTICS, ANTITUSSIVE, AND STIMULANTS OF THE PRODUCTION OF THE SURFACTANT OR ANTIATELECTASIS FACTOR OF THE ALVEOLI.

Inventors

• 👤 Johannes Keck
• 👤 Klaus-Reinhold Noll
• 👤 Helmut Pieper
• 👤 Gerd Kruger
• 👤 Sigfrid Puschmann

Bibliographic Details