Patent US3949089A successfully refreshed from Google Patents.
US3949089A
Expired / Lapsed
US
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Substituted guanidine compounds as antifibrillatory agents
Assignee: SmithKline Beecham Corp
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Filing: 1974-01-14
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Granted: 1976-04-06
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Expires: 1994-01-14
Abstract
Abstract Acid addition salts of N-p-methylbenzyl-N',N"-dimethylguanidine and of N-p-methoxybenzyl-N',N"-dimethylguanidine. The compounds have antiarrhythmic properties, and are useful specifically as antifibrillatory agents.
Inventors
- 👤 Robert Arthur Maxwell
- 👤 Eric Walton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/155
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
32 words
A method of treatment of arrhythmia in a mammal suffering from arrhythmia which comprises administering to said mammal an effective arrhythmia treatment amount of a pharmaceutically acceptable acid addition salt of N-p-methoxybenzyl-N',N"-dimethylguanidine.
Claim 2
Independent Claim
32 words
A method of treatment of arrhythmia in a mammal suffering from arrhythmia which comprises administering to said mammal an effective arrhythmia treatment amount of a pharmaceutically acceptable acid addition salt of N-p-methoxybenzyl-N',N"-dimethylguanidine.
Claim 3
Dependent Claim
15 words
A method according to claim 1 wherein the arrhythmia which is treated is atrial fibrillation.
Claim 4
Dependent Claim
12 words
A method according to claim 2 wherein the mammal is a human.
Claim 5
Dependent Claim
19 words
A method according to claim 1 in which the acid addition salt is the sulphate salt of N-p-methoxybenzyl-N',N" -dimethylguanidine.
Claim 6
Dependent Claim
22 words
A method according to claim 1 wherein the effective amount is 1 to 10 mg of the base /kg of mammal bodyweight.
Claim 7
Dependent Claim
17 words
A method according to claim 5 wherein the arrhythmia which is treated is ventricular or atrial fibrillation.
Claim 8
Independent Claim
39 words
A method of suppressing ventricular or atrial fibrillations in a mammal having a heart disorder which comprises administering to said mammal an effective ventricular or atrial fibrillation suppression amount of a pharmaceutically acceptable acid addition salt of N-p-methoxybenzyl-N',N" -dimethylguanidine.
Claim 9
Independent Claim
39 words
A method of suppressing ventricular or atrial fibrillations in a mammal having a heart disorder which comprises administering to said mammal an effective ventricular or atrial fibrillation suppression amount of a pharmaceutically acceptable acid addition salt of N-p-methoxybenzyl-N',N" -dimethylguanidine.
Claim 10
Dependent Claim
20 words
A method according to claim 7 in which the fibrillation and the amount is an effective ventricular fibrillation suppression amount.
Claim 11
Dependent Claim
19 words
A method according to claim 8 in which the acid addition salt is the sulphate salt of N-p-methoxybenzyl-N',N" -dimethylguanidine.
Claim 12
Dependent Claim
23 words
A method according to claim 8 in which said effective amount is 1 to 10 mg. of the base /kg. of mammal bodyweight.
Claim 13
Dependent Claim
23 words
A method according to claim 7 in which an effective amount is 1 to 10 mg of the base /kg of mammal bodyweight.
Claim 14
Dependent Claim
40 words
A pharmaceutical composition in solid form for administration to treat or suppress arrhythmia, comprising per dosage unit an effective arrhythmia treatment or suppression amount of a pharmaceutically acceptable acid addition salt of N-p-methoxybenzyl-N', N"-dimethylguanidine and a therapeutically acceptable carrier therefor.
Claim 15
Dependent Claim
40 words
A pharmaceutical composition in solid form for administration to treat or suppress arrhythmia, comprising per dosage unit an effective arrhythmia treatment or suppression amount of a pharmaceutically acceptable acid addition salt of N-p-methoxybenzyl-N', N"-dimethylguanidine and a therapeutically acceptable carrier therefor.
Claim 16
Dependent Claim
26 words
A composition according to claim 12 in which the arrhythmia is ventricular or atrial fibrillation and the effective amount is a ventricular or atrial fibrillation amount.
Claim 17
Dependent Claim
16 words
A composition according to claim 13 in which the salt is the sulphate salt of N-p-methoxybenzyl-N',N"-dimethylguanidine.
Claim 18
Dependent Claim
13 words
A pharmaceutical composition according to claim 12 in a form for oral administration.
Claim 19
Dependent Claim
15 words
A pharmaceutical composition according to claim 15 in the form of a tablet or capsule.
Claim 20
Dependent Claim
23 words
A pharmaceutical composition according to claim 15 in the form of a discrete dosage unit containing 100 to 600 mg of the base.
References Cited (Backward Citations)
US3168562A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-06 | 1979-10-06 | 1980-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-06 | 1983-10-06 | 1984-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-06 | 1987-10-06 | 1988-04-06 | $7700.00 | Window Closed / Lapsed |