US3941799A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6-Substituted-11b-phenyl-3, 11bH-oxazirino[2,3-d]-s-triazol[4,3-a][1,4]benzodiazepines
Assignee: Novartis Corp
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Filing: 1973-05-16
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Granted: 1976-03-02
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Expires: 1993-05-16
Abstract
Abstract Compounds of the class of 6-substituted 11b-phenyl-3,11b-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4]benzodiazepines have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an anticonvulsive action and inhibit somatic reflexes. Specific embodiments are 10-chloro-11b-phenyl-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4] benzodiazepine-6-methanol, 10-chloro-11b-phenyl-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4]benzodiazepine-6-carboxaldehyde-diethylacetal and 10-chloro-11b-(o-chlorophenyl)-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a][1,4]benzodiazepine-6-carboxaldehyde-diethylacetal.
Inventors
- 👤 Hans Allgeier
- 👤 Andre Gagneux
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:11
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
110 words
A diazepine derivative having the formula I ##SPC4## wherein R 1 represents hydrogen or an alkyl group having 1 to 3 carbon atoms, A represents an alkylene group having 1 to 3 carbon atoms, R 2 represents a hydroxyl group, benzyloxy, o-, m- or p-chlorobenzyloxy o-, m- or p-methylbenzyloxy, o-, m- or p-methoxybenzyloxy, or diphenylmethoxy group, or R 2 --a together represent a dialkoxymethyl group of which the alkoxy radicals contain 1 to 4 carbon atoms, and each of the rings B and C, independently of the other, is unsubstituted or mono-substituted by halogen up to atomic number 35, trifluoromethyl, alkyl or alkoxy groups having 1 to 6 carbon atoms.
Claim 2
Dependent Claim
110 words
A diazepine derivative having the formula I ##SPC4## wherein R 1 represents hydrogen or an alkyl group having 1 to 3 carbon atoms, A represents an alkylene group having 1 to 3 carbon atoms, R 2 represents a hydroxyl group, benzyloxy, o-, m- or p-chlorobenzyloxy o-, m- or p-methylbenzyloxy, o-, m- or p-methoxybenzyloxy, or diphenylmethoxy group, or R 2 --a together represent a dialkoxymethyl group of which the alkoxy radicals contain 1 to 4 carbon atoms, and each of the rings B and C, independently of the other, is unsubstituted or mono-substituted by halogen up to atomic number 35, trifluoromethyl, alkyl or alkoxy groups having 1 to 6 carbon atoms.
Claim 3
Dependent Claim
56 words
A compound according to claim 1, having the formula I given in claim 1 wherein R 1 represents hydrogen, R 2 represents the hydroxyl, benzyloxy or p-methoxybenzyloxy group, A represents the methylene group, ring B is substituted in the 10-position by chlorine, and ring C is unsubstituted or substituted in the o-position by fluorine or chlorine.
Claim 4
Dependent Claim
52 words
A compound according to claim 1 having the formula I given in claim 1, wherein R 1 represents hydrogen, R 2 --A together represent the dimethoxymethyl or diethoxymethyl group, ring B is substituted in the 10-position by chlorine, and ring C is unsubstituted or substituted in the o-position by fluorine or chlorine.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, which is 10-chloro-11b-phenyl-3,11bH-oxazirino[2,3-d]-s-triazolo[4,3-a] [1,4]benzodiazepine-6-methanol.
Claim 6
Dependent Claim
12 words
A compound according to claim 1 which is 10-chloro-11b-phenyl-3,11bH-oxazirino[2,3-d]-s-triazolo[ 4,3-a] [1,4] benzodiazepine-6carboxaldehyde-diethylacetal.
Claim 7
Dependent Claim
11 words
A compound according to Claim 1, which is 10-chloro-11b-(o-chlorophenyl)-3,11bH-oxazirino[ 2,3-d]-s-triazolo[4,3-a] [1,4]benzodiazepine-6-carboxaldehyde-diethylacetal.
References Cited (Backward Citations)
US3681343A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-02 | 1979-09-01 | 1980-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-02 | 1983-09-01 | 1984-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-02 | 1987-09-01 | 1988-03-02 | $7700.00 | Window Closed / Lapsed |