Patent US3940383A successfully refreshed from Google Patents.
US3940383A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Streptozotocin analogs
Assignee: SRI International Inc
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Filing: 1974-12-12
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Granted: 1976-02-24
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Expires: 1994-12-12
Abstract
Abstract New 3-methyl-3-nitrosoureido derivatives of the following amino sugars were prepared as analogs of streptozotocin with the anomeric carbon protected, by nitrosating the methylureas in water with N 2 O 3 : 3-amino-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose; methyl 3-amino-3-deoxy-β-D-xylopyranoside; methyl 3-amino-3-deoxy-α-D-altropyranoside; methyl 3-amino-3-deoxy-α-D-glucopyranoside; and methyl 3-amino-2,3,6-trideoxy-α-L-lyxohexopyranoside. Tests against murine leukemia L1210 show that the anticancer activity of streptozotocin not only was retained but was enhanced in most of these derivatives.
Inventors
- 👤 Allan N. Fujiwara
- 👤 Edward M. Acton
- 👤 David W. Henry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:44
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
18 words
The 3-methyl-3-nitrosoureido derivatives of the following amino sugars: methyl 3-amino-3-deoxy-β-D-xylopyranoside; methyl 3-amino-3-deoxy-α-D-altropyranoside; 3-amino-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose; methyl 3-amino-2,3,6-trideoxy-α-L-lyxohexopyranoside; and methyl 3-amino-3-deoxy-α-D-glucopyranoside.
Claim 2
Dependent Claim
18 words
The 3-methyl-3-nitrosoureido derivatives of the following amino sugars: methyl 3-amino-3-deoxy-β-D-xylopyranoside; methyl 3-amino-3-deoxy-α-D-altropyranoside; 3-amino-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose; methyl 3-amino-2,3,6-trideoxy-α-L-lyxohexopyranoside; and methyl 3-amino-3-deoxy-α-D-glucopyranoside.
Claim 3
Dependent Claim
9 words
The compound of claim 1 which is methyl 3-deoxy-3-(3-methyl-3-nitrosoureido)-β-D-xylopyranoside.
Claim 4
Dependent Claim
9 words
The compound of claim 1 which is methyl 3-deoxy-3-(3-methyl-3-nitrosoureido)-α-D-altorpyranoside.
Claim 5
Dependent Claim
8 words
The compound of claim 1 which is 3-deoxy-1,2-O-isopropylidene-3-(3-methyl-3-nitrosoureido)-α-D-ribofuranose.
Claim 6
Dependent Claim
9 words
The compound of claim 1 which is methyl 2,3,6-trideoxy-3-(3-methyl-3-nitrosoureido)-α-L-lyxohexopyranoside.
Claim 7
Dependent Claim
9 words
The compound of claim 1 which is methyl 3-deoxy-3-(3-methyl-3-nitrosoureido)-α-D-glucopyranoside.
References Cited (Backward Citations)
US3767640A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-23 | 1979-08-25 | 1980-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-23 | 1983-08-25 | 1984-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-23 | 1987-08-25 | 1988-02-24 | $7700.00 | Window Closed / Lapsed |