Patent US3939172A successfully refreshed from Google Patents.
US3939172A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Aminothiazole
Assignee: GlaxoSmithKline LLC
•
Filing: 1974-11-07
•
Granted: 1976-02-17
•
Expires: 1994-11-07
Abstract
Abstract 4-Aminothiazole is prepared in stable useful form by alkaline hydrolysis of 4-trifluoroacetamidothiazole. Also prepared are 4-sulfathiazole and 2-(4-thaizolyl)-indazole.
Inventors
- 👤 Gregory Gallagher, Jr.
- 👤 William D. Kingsbury
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:40
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/38; C07D277/50; C07D277/52; C07D277/40; C07D277/44; C07D277/46
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
6 words
4-Aminothiazole and its acid addition salts.
Claim 2
Dependent Claim
6 words
4-Aminothiazole and its acid addition salts.
Claim 3
Dependent Claim
12 words
The compound of claim 1 being the base of the structure: ##SPC1##
Claim 4
Dependent Claim
11 words
The compound of claim 1 being the hydrochloride salt of 4-aminothiazole.
Claim 5
Dependent Claim
6 words
4-Trifluoroacetamidothiazole and its acid addition salts.
Claim 6
Dependent Claim
6 words
4-Trifluoroacetamidothiazole and its acid addition salts.
Claim 7
Dependent Claim
12 words
The compound of claim 4 being the base of the structure: ##SPC2##
Claim 8
Dependent Claim
12 words
The compound of claim 4 being the trifluoroacetic acid salt of 4-trifluoroacetamidothiazole.
Claim 9
Independent Claim
35 words
The method of preparing 4-aminothiazole comprising reacting 4-trifluoroacetamidothiazole with an ammonium or alkali metal hydroxide in an aqueous medium at from about room temperature up to about 40°C. until the hydrolysis reaction is substantially complete.
Claim 10
Independent Claim
35 words
The method of preparing 4-aminothiazole comprising reacting 4-trifluoroacetamidothiazole with an ammonium or alkali metal hydroxide in an aqueous medium at from about room temperature up to about 40°C. until the hydrolysis reaction is substantially complete.
Claim 11
Dependent Claim
22 words
The method of claim 7 in which the hydroxide is sodium or potassium hydroxide and the temperature range is from about 30°-35°C.
Claim 12
Dependent Claim
15 words
The method of claim 8 in which the reaction time is from about 4-8 hours.
Claim 13
Independent Claim
46 words
The method of preparing 4-aminothiazole comprising reacting 2-bromo-4-trifluoroacetamidothiazole under low pressure catalytic hydrogenation conditions in the presence of a noble metal catalyst to give 4-trifluoroacetamidothiazole then reacting said 4-trifluoroacetamidothiazole with sodium or potassium hydroxide in an aqueous medium at from about 30°-35°C. for about 4-8 hours.
Claim 14
Independent Claim
46 words
The method of preparing 4-aminothiazole comprising reacting 2-bromo-4-trifluoroacetamidothiazole under low pressure catalytic hydrogenation conditions in the presence of a noble metal catalyst to give 4-trifluoroacetamidothiazole then reacting said 4-trifluoroacetamidothiazole with sodium or potassium hydroxide in an aqueous medium at from about 30°-35°C. for about 4-8 hours.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-16 | 1979-08-18 | 1980-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-16 | 1983-08-18 | 1984-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-16 | 1987-08-18 | 1988-02-17 | $7700.00 | Window Closed / Lapsed |