US3937819A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of stabilizing an injectable composition of a cholecystokinin active octapeptide
Assignee: ER Squibb and Sons LLC
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Filing: 1974-07-22
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Granted: 1976-02-10
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Expires: 1994-07-22
Abstract
Abstract A stable composition of the sulfated octapeptide, ##EQU1## having cholecystokinin activity, is obtained by lyophilizing an aqueous solution of the octapeptide and NaCl.
Inventors
- 👤 Miguel Angel Ondetti
- 👤 Charles Riffkin
- 👤 Bernard Rubin
- 👤 Aaron L. Weiss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:26
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K47/00; A61K47/02; A61K9/00; A61K9/0012; A61K9/0019; A61K9/14; A61K9/19; A61P; A61P1/00; A61P1/16
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
73 words
A method of enhancing the stability of the octapeptide ##EQU8## against degradation during storage, which comprises lyophilizing a solution containing per liter about 2500 mcg of said octapeptide and about 21.43 g of sodium chloride, and a sufficient quantity of water for injection to adjust the volume to about 1 liter, the pH of the solution being adjusted to from 5.50 to 6.50, if necessary, by addition of sodium hydroxide or hydrochloric acid.
Claim 2
Independent Claim
73 words
A method of enhancing the stability of the octapeptide ##EQU8## against degradation during storage, which comprises lyophilizing a solution containing per liter about 2500 mcg of said octapeptide and about 21.43 g of sodium chloride, and a sufficient quantity of water for injection to adjust the volume to about 1 liter, the pH of the solution being adjusted to from 5.50 to 6.50, if necessary, by addition of sodium hydroxide or hydrochloric acid.
References Cited (Backward Citations)
US3723406A
Cited
US3734946A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-02-09 | 1979-08-11 | 1980-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-02-09 | 1983-08-11 | 1984-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-02-09 | 1987-08-11 | 1988-02-10 | $7700.00 | Window Closed / Lapsed |