US3723406A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel peptides having cholecystokinin activity and intermediates therefor
Assignee: ER Squibb and Sons LLC
•
Filing: 1969-12-23
•
Granted: 1973-03-27
•
Expires: 1989-12-23
Abstract
Abstract Novel peptide amides of the general formula
Inventors
- 👤 M Ondetti
- 👤 J Jorpes
- 👤 V Mutt
- 👤 J Pluscec
- 👤 J Sheehan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 04:59
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/595; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
27 words
A compound according to claim 1 of the formula R-NHNH2 wherein R is N-protected-L-arginyl-L-aspartyl-L-tyrosyl or N-protected L-aspartyl-L-arginyl-L-aspartyl-L-tyrosyl wherein the N-protecting group is benzyloxycarbonyl, t-butyloxycarbonyl, trifluoroacetyl or X-nitrophenylsulfenyl.
Claim 2
Dependent Claim
12 words
A compound in accordance with claim 2 having the name tert.-butyloxycarbonyl-L-aspartyl-L-arginyl-L-aspartyl-L-tyrosine hydrazide.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 2 having the name tert.-butyloxycarbonyl-L-arginyl-L-aspartyl-L-tyrosine hydrazide.
Claim 4
Dependent Claim
88 words
A hydrazide having the formula R-NHNH-Y wherein R is X-protected nitro-L-arginyl- Beta -protected L-aspartyl-L-tyrosyl, nitro-L-arginyl- Beta -protected L-aspartyl-L-tyrosyl, or X-protected- Beta -benzyl-L-aspartyl-nitro-L-arginyl- Beta -protected L-aspartyl-L-tyrosyl, and acid-addition salts thereof; and wherein X and Y are different amino protecting groups selected from the group consisting of benzyloxycarbonyl, t-butyloxycarbonyl, trifluoroacetyl and o-nitrophenylsulfenyl, provided that when one of X or Y is t-butyloxycarbonyl, the other protecting group is other than o-nitrophenylsulfenyl, the hydroxyl protecting group being benzyl, tert.-butyl or tetrahydropyranyl, and the Beta -carboxyl protecting group being benzyl or lower alkyl.
Claim 5
Dependent Claim
84 words
A hydrazide according to claim 5 having the formula R-NHNH-Y wherein R is X-protected nitro-L-arginyl- Beta -protected L-aspartyl-L-tyrosyl, nitro-L-arginyl- Beta -protected L-aspartyl-L-tyrosyl, or X-protected- Beta -benzyl-L-aspartyl-nitro-L-arginyl- Beta -protected L-aspartyl-L-tyrosyl, and acid-addition salts thereof; and wherein X and Y are different amino protecting groups selected from the group consisting of benzyloxycarbonyl, t-butyloxycarbonyl, trifluoroacetyl and o-nitrophenylsulfenyl, provided that when one of X or Y is t-butyloxycarbonyl, the other protecting group is other than o-nitrophenylsulfenyl, and wherein the Beta -carboxyl protecting group is benzyl or lower alkyl.
Claim 6
Dependent Claim
14 words
A compound in accordance with claim 6 having the name tert.-butyloxycarbonylnitro-L-arginyl- Beta -benzyl-L-aspartyl-L-tyrosine benzyloxycarbonylhydrazide.
Claim 7
Dependent Claim
15 words
A compound in accordance with claim 6 having the name nitro-L-arginyl- Beta -benzyl-L-aspartyl-L-tyrosine benzyloxycarbonylhydrazide trifluoroacetate.
Claim 8
Dependent Claim
16 words
A compound in accordance with claim 5 having the name tert.-butyloxycarbonyl- Beta -benzyl-L-aspartyl-nitro-L-arginyl- Beta -benzyl-L-aspartyl-L-tyrosine benzyloxycarbonylhydrazide.
References Cited (Backward Citations)
US3250760A
Cited
US3296243A
Cited
US3400118A
Cited
US3472832A
Cited
US3475403A
Cited
US3488726A
Cited
US3579494A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-03-26 | 1976-09-25 | 1977-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-03-26 | 1980-09-25 | 1981-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-03-26 | 1984-09-25 | 1985-03-27 | $7700.00 | Window Closed / Lapsed |