Reducing the incidence of gastrointestinal side effects during the treatment of inflammatory conditions with antiinflammatory drugs

Abstract

Abstract A method is disclosed for inhibiting and alleviating gastrointestinal side effects often encountered during therapy with antiinflammatory agents such as indomethacin, phenylbutazone, oxyphenylbutazone and the like. The method comprises the administration to a mammal receiving such therapy of a prostaglandin derivative of formula 1, ##SPC1## In which A. W is C = O, X and Y each are single bonds, Z is either C = O, CHOH or C(CH 3 )OH, R 1 and R 2 each are hydrogen, R 3 is (CH 2 ) 3 CH 3 and R 4 is hydrogen or lower alkyl; B. W is CHOH, X and Y each are single bonds, Z is either CHOH or C(CH 3 )OH, R 1 and R 2 each are hydrogen, R 3 is (CH 2 ) 3 CH 3 and R 4 is hydrogen or lower alkyl; C. W is C = O, X is a single bond, Y is a trans double bond, Z is CH 2 , CHOH or C(CH 3 )OH, R 1 and R 2 each are hydrogen and R 3 is (CH 2 ) 3 CH 3 and R 4 is hydrogen or lower alkyl; D. W is C = O, X is a single bond, Y is a trans double bond, Z is CHOH, R 1 and R 2 each are hydrogen, R 3 is cyclohexyl and R 4 is hydrogen or lower alkyl; E. W is C = O, X is a cis double bond, Y is a trans double bond, Z is CHOH, or C(CH 3 )OH, R 1 is hydrogen and R 2 is hydrogen or methyl, R 3 is (CH 2 ) 3 CH 3 and R 4 is hydrogen or lower alkyl; or F. W is C = O, X is a cis double bond, Y is a trans double bond, Z is CHOH, R 1 and R 2 each are methyl, R 3 is (CH 2 ) 3 CH 3 and R 4 is hydrogen or lower alkyl. Also disclosed are useful pharmaceutical compositions for treating inflammatory conditions comprising a combination of a gastrointestinal side effect-inhibiting dose of the above prostaglandin derivative of formula 1 and a therapeutic dose of an antiinflammatory agent.

Inventors

• 👤 Wilbur Lippmann

Bibliographic Details