US3935071A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the conversion of glucose into gluconic acid
Assignee: Roche Diagnostics GmbH
•
Filing: 1973-03-13
•
Granted: 1976-01-27
•
Expires: 1993-03-13
Abstract
Abstract Glucose is converted into gluconic acid by oxidation with oxygen in aqueous solution, by a process comprising passing a glucose containing aqueous solution over a catalyst which contains glucose oxidase and catalase, bound to an appropriate carrier, in immediate proximity to one another. The process avoids the disadvantage of previous catalytic processes depending on catalysts which rapidly lose their activity and is adapted to large-scale operation.
Inventors
- 👤 Hans Ulrich Bergmeyer
- 👤 Dieter Jaworek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:30
CPC Classifications
C; C12; C12P; C12P7/00; C12P7/40; C12P7/58; C07; C07C; C07C51/00; C07C51/16; C07C51/31; C07C51/313; C12N; C12N11/00; C12N11/18; Y; Y02; Y02P; Y02P20/00; Y02P20/50
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
53 words
Process for the conversion of glucose into gluconic acid by enzymatic oxidation in the presence of oxygen in aqueous solution, which process comprises passing a glucose-containing aqueous solution over a catalyst comprising an insoluble gel carrier to which is bound a mixture of glucose oxidase and catalase in close side by side proximity.
Claim 2
Dependent Claim
53 words
Process for the conversion of glucose into gluconic acid by enzymatic oxidation in the presence of oxygen in aqueous solution, which process comprises passing a glucose-containing aqueous solution over a catalyst comprising an insoluble gel carrier to which is bound a mixture of glucose oxidase and catalase in close side by side proximity.
Claim 3
Dependent Claim
14 words
Process as claimed in claim 1, wherein oxygen is passed into the glucose-containing solution.
Claim 4
Dependent Claim
18 words
Process as claimed in claim 1, wherein the pH during the reaction is maintained between 3.5 and 8.
Claim 5
Dependent Claim
18 words
Process as claimed in claim 3, wherein the pH during the reaction is maintained between 4.7 and 7.
Claim 6
Dependent Claim
18 words
Process as claimed in claim 4, wherein the pH during the reaction is maintained between 5 and 5.5.
Claim 7
Dependent Claim
17 words
Process as claimed in claim 3, wherein the pH is controlled by the addition of a lye.
Claim 8
Dependent Claim
18 words
Process as claimed in claim 3, wherein the pH is controlled by removal of the gluconic acid formed.
Claim 9
Dependent Claim
18 words
Process as claimed in claim 1, wherein the reaction is carried out continuously by recycling the treated solution.
Claim 10
Dependent Claim
20 words
Process as claimed in claim 8, wherein the catalyst is fixed in a column through which the reactants are passed.
Claim 11
Dependent Claim
23 words
Process as claimed in claim 8, wherein the gluconic acid formed is removed from the solution before recycling the solution to the catalyst.
Claim 12
Dependent Claim
27 words
Process as claimed in claim 10, wherein the gluconic acid is removed by treatment with an anion exchanger or by conversion into a sparingly soluble derivative thereof.
Claim 13
Dependent Claim
19 words
Process as claimed in claim 1, wherein the reaction is carried out at a temperature between 10° and 60°C.
Claim 14
Dependent Claim
19 words
Process as claimed in claim 12, wherein the reaction is carried out at a temperature between 25° and 50°C.
Claim 15
Dependent Claim
20 words
Process as claimed in claim 1, wherein the ratio of activities of glucose oxidase to catalase is less than 1:1.
Claim 16
Dependent Claim
21 words
Process as claimed in claim 14, wherein the ratio of activities of glucose oxidase to catalase is from 1:10 to 1:200.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-26 | 1979-07-28 | 1980-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-26 | 1983-07-28 | 1984-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-26 | 1987-07-28 | 1988-01-27 | $7700.00 | Window Closed / Lapsed |