US3933996A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition comprising radioactive labeled-fibrinogen and albumin
Assignee: GE Healthcare Ltd
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Filing: 1973-06-19
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Granted: 1976-01-20
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Expires: 1993-06-19
Abstract
Abstract The stability of fibrinogen is improved by mixing it with albumin, preferably at least 5 parts by weight of albumin per part by weight of fibrinogen. By this invention, iodinated (125I) human fibrinogen can be stabilised with human serum albumin for use in the diagnosis of thrombi.
Inventors
- 👤 John Cecil Charlton
- 👤 David Lawrence Gravett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:30
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K38/00; A61K38/16; A61K38/17; A61K38/36; A61K38/363; A61K2121/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
35 words
A solid product comprising one part by weight of fibrinogen labelled with a radioactive iodine isotope, and from 1 to 1,000 parts by weight of albumin to reduce or prevent unwanted decomposition of the fibrinogen.
Claim 2
Dependent Claim
35 words
A solid product comprising one part by weight of fibrinogen labelled with a radioactive iodine isotope, and from 1 to 1,000 parts by weight of albumin to reduce or prevent unwanted decomposition of the fibrinogen.
Claim 3
Dependent Claim
15 words
A solid product as claimed in claim 1, wherein the fibrinogen is labelled with iodine-125.
Claim 4
Dependent Claim
21 words
A solid product as claimed in claim 1, wherein the fibrinogen is human fibrinogen and the albumin is human serum albumin.
Claim 5
Dependent Claim
25 words
A solid product as claimed in claim 1, containing at least 5 parts by weight of the albumin per part by weight of the fibrinogen.
Claim 6
Dependent Claim
25 words
A solid product as claimed in claim 1, containing 20 - 1,000 parts by weight of the albumin per part by weight of the fibrinogen.
Claim 7
Dependent Claim
49 words
A method of making the solid product claimed in claim 1, which comprises removing water from an aqueous solution or suspension of one part by weight of the fibrinogen containing from 1 to 1,000 parts by weight of the albumin to reduce or prevent unwanted decomposition of the fibrinogen.
Claim 8
Dependent Claim
16 words
A method as claimed in claim 6, wherein the removal of water is effected by freeze-drying.
Claim 9
Dependent Claim
30 words
A method as claimed in claim 6, wherein the aqueous solution or suspension contains 20 - 1,000 parts by weight of the albumin per part by weight of the fibrinogen.
Claim 10
Dependent Claim
38 words
A solid product comprising fibrinogen iodinated with iodine-125 and from 5 to 1000 parts by weight of albumin per part by weight of fibrinogen, wherein the proportion ##EQU2## remains above 0.5 during storage for one month at 2°C.
Claim 11
Dependent Claim
38 words
A solid product comprising fibrinogen iodinated with iodine-125 and from 5 to 1000 parts by weight of albumin per part by weight of fibrinogen, wherein the proportion ##EQU2## remains above 0.5 during storage for one month at 2°C.
Claim 12
Dependent Claim
25 words
A solid product as claimed in claim 9, containing 20 - 1,000 parts by weight of the albumin per part by weight of the fibrinogen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-19 | 1979-07-21 | 1980-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-19 | 1983-07-21 | 1984-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-19 | 1987-07-21 | 1988-01-20 | $7700.00 | Window Closed / Lapsed |