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US3932479A
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Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates
Assignee: Wyeth Holdings LLC
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Filing: 1973-04-27
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Granted: 1976-01-13
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Expires: 1993-04-27
Abstract
Abstract This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.
Inventors
- 👤 Karel Francis Bernady
- 👤 Middleton Brawner Floyd, Jr.
- 👤 John Frank Poletto
- 👤 Robert Eugene Schaub
- 👤 Martin Joseph Weiss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 12:32
CPC Classifications
C; C07; C07F; C07F5/00; C07F5/06; C07F5/061; C07F5/062; C07C; C07C29/00; C07C29/36; C07C29/38; C07C29/42; C07C33/00; C07C33/40; C07C33/42; C07C33/423; C07C405/00; C07C43/00; C07C43/02; C07C43/03; C07C43/04; C07C43/12; C07C51/00; C07C51/347; C07C51/377; C07C51/38; C07C53/00; C07C53/15; C07C53/19; C07C53/38; C07C53/46; C07C53/50; C07C59/00; C07C59/01; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07D309/34; C07D309/36; C07D309/38; C07F1/00; C07F1/02; C07F9/00; C07F9/02; C07F9/28; C07F9/54; C07F9/5407; C07B; C07B2200/00; C07B2200/09
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
193 words
Compounds of the formula: ##EQU22## wherein R' is an alkyl group having from 1 to 10 carbon atoms which may be different when t is greater than one; R is selected from the group consisting of a straight chain alkyl group having from 2 to 10 carbon atoms, a straight chain alkyl group having from 2 to 10 carbon atoms and substituted with one or two alkyl groups having from one to three carbon atoms, a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and substituted with one or two alkyl groups having between them 2 to 5 carbon atoms; W is selected from a group consisting of lower alkyl, triphenylmethyl, triphenylmethyl in which one or two of the phenyl rings is substituted with a lower alkoxy group, tetrahydropyranyl, α-(lower alkoxy) substituted lower alkyl and tri(lower alkyl)silyl; s is an integer having the value of one to three, inclusive, and t is an integer having the values of one to three, inclusive, with the proviso that the sum of s and t must be equal to four.
Claim 2
Dependent Claim
193 words
Compounds of the formula: ##EQU22## wherein R' is an alkyl group having from 1 to 10 carbon atoms which may be different when t is greater than one; R is selected from the group consisting of a straight chain alkyl group having from 2 to 10 carbon atoms, a straight chain alkyl group having from 2 to 10 carbon atoms and substituted with one or two alkyl groups having from one to three carbon atoms, a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and substituted with one or two alkyl groups having between them 2 to 5 carbon atoms; W is selected from a group consisting of lower alkyl, triphenylmethyl, triphenylmethyl in which one or two of the phenyl rings is substituted with a lower alkoxy group, tetrahydropyranyl, α-(lower alkoxy) substituted lower alkyl and tri(lower alkyl)silyl; s is an integer having the value of one to three, inclusive, and t is an integer having the values of one to three, inclusive, with the proviso that the sum of s and t must be equal to four.
Claim 3
Dependent Claim
27 words
The compound according to claim 1 wherein s is one, t is three, R is n-pentyl, R' is methyl, and W is triphenylmethyl; lithium trimethyl 3-triphenylmethoxy-1-trans-octenyl alanate.
Claim 4
Dependent Claim
27 words
The compound according to claim 1 wherein s is one, t is three, R is cis-2-pentenyl, R' is methyl, and W is triphenylmethyl; lithium trimethyl 3-triphenylmethoxy-1-trans,5-cis-octadienyl alanate.
Claim 5
Dependent Claim
103 words
Compounds of the formula: ##EQU23## wherein R is lower alkyl; R° is lower alkyl; and R' is selected from the group consisting of a straight chain alkyl group having from 2 to 10 carbon atoms, a straight chain alkyl group having from 2 to 10 carbon atoms and substituted with one or two alkyl groups having from one to three carbon atoms, a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and substituted with one or two alkyl groups having between them 2 to 5 carbon atoms.
Claim 6
Dependent Claim
103 words
Compounds of the formula: ##EQU23## wherein R is lower alkyl; R° is lower alkyl; and R' is selected from the group consisting of a straight chain alkyl group having from 2 to 10 carbon atoms, a straight chain alkyl group having from 2 to 10 carbon atoms and substituted with one or two alkyl groups having from one to three carbon atoms, a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and a straight chain alkenylmethyl group having from 3 to 10 carbon atoms and substituted with one or two alkyl groups having between them 2 to 5 carbon atoms.
Claim 7
Dependent Claim
20 words
The compound according to claim 4 wherein R and R° are methyl and R' is n-pentyl; lithium 3-triphenylmethoxy-1-trans-octenyl diisobutylmethyl alanate.
Claim 8
Dependent Claim
20 words
The compound according to claim 4 wherein R and R° are methyl and R' is n-butyl; lithium 3-triphenylmethoxy-1-trans-heptenyl diisobutylmethyl alanate.
Claim 9
Dependent Claim
20 words
The compound according to claim 4 wherein R and R° are methyl and R' is n-hexyl; lithium 3-triphenylmethoxy-1-trans-nonenyl diisobutylmethyl alanate.
Claim 10
Dependent Claim
20 words
The compound according to claim 4 wherein R and R° are methyl and R' is cis-2-pentenyl; lithium 3-triphenylmethoxy-5-cis-1-trans-octadienyl diisobutylmethyl alanate.
Claim 11
Dependent Claim
19 words
The compound according to claim 4 wherein R and R° are methyl and R' is 1-ethyl-n-pentyl; lithium-3-triphenylmethoxy-4-ethyl-1-trans-octenyl diisobutylmethyl alanate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-12 | 1979-07-14 | 1980-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-12 | 1983-07-14 | 1984-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-12 | 1987-07-14 | 1988-01-13 | $7700.00 | Window Closed / Lapsed |