US3930004A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of using phenoxypropanolpiperazine compounds to lower blood pressure
Assignee: Pfizer Inc
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Filing: 1974-08-02
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Granted: 1975-12-30
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Expires: 1994-08-02
Abstract
Abstract A series of novel substituted phenoxypropyl piperazine derivatives have been prepared by reacting the appropriate 1phenoxy-2,3-epoxypropane compound with a suitable Nphenylpiperazine reagent. The resulting 1-phenoxy-3-(4phenylpiperazine-1-yl) propan-2-ols are useful in the field of chemotherapy as antihypertensive agents. Preferred members include compounds having an acetamidomethyl, carboxymethyl or carbamoylmethyl group substituted on the phenyl ring of the phenoxy moiety. Alternate methods of preparation are also provided.
Inventors
- 👤 John Christopher Danilewicz
- 👤 John Edward Glyn Kemp
- 👤 Michael Snarey
- 👤 James Robert Wright
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:05
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; H; H04; H04N; H04N5/00; H04N5/76; H04N5/91; H04N5/92; H04N5/9201; H04N5/9206; H04N5/9207
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
A METHOD FOR LOWERING BLOOD PRESSURE IN THE TREATMENT OF A HYPERTENSIVE SUBJECT, WHICH COMPRISES ADMINISTERING TO SAID SUBJECT AN EFFECTIVE BLOOD PRESSURE LOWERING AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF A PHENOXYPROPANOLPIPERAZINE BASE OF THE FORMULA:
Claim 2
Independent Claim
40 words
A METHOD FOR LOWERING BLOOD PRESSURE IN THE TREATMENT OF A HYPERTENSIVE SUBJECT, WHICH COMPRISES ADMINISTERING TO SAID SUBJECT AN EFFECTIVE BLOOD PRESSURE LOWERING AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF A PHENOXYPROPANOLPIPERAZINE BASE OF THE FORMULA:
Claim 3
Dependent Claim
14 words
The method as claimed in claim 1 wherein the compound administered is 1-(4-acetamidomethylphenoxy)-3-(4-(2-methoxyphenylpiperazin-1-yl)propan-2 -ol.
Claim 4
Dependent Claim
14 words
The method as claimed in claim 1 wherein the compound administered is 1-(2-carboxymethylphenoxy)-3-(4-(2-methoxyphenyl)-piperazin-1-yl)propan-2 -ol.
Claim 5
Dependent Claim
14 words
The method as claimed in claim 1 wherein the compound administered is 1-(2-carbamoylmethylphenoxy)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-2 -ol.
Claim 6
Dependent Claim
14 words
The method as claimed in claim 1 wherein the compound administered is 1-(2-methyl-4-carbamoylmethylphenoxy)-3-(4-(2-methoxyphenyl)piperazin-1 -yl)propan-2-ol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-29 | 1979-06-30 | 1979-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-29 | 1983-06-30 | 1983-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-29 | 1987-06-30 | 1987-12-30 | $7700.00 | Window Closed / Lapsed |