US3856794A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-phenoxy-3-arylpiperazinyl-2-propanol hypotensives
Assignee: United Stirling AB and Co
•
Filing: 1971-11-08
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Granted: 1974-12-24
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Expires: 1991-11-08
Abstract
Abstract A series of novel substituted phenoxypropyl piperazine derivatives have been prepared by reacting the appropriate 1phenoxy-2,3-epoxypropane compound with a suitable Nphenylpiperazine reagent. The resulting 1-phenoxy-3-(4phenylpiperazine-1-yl) propan-2-ols are useful in the field of chemotherapy as antihypertensive agents. preferred members include compounds having an acetamidomethyl, carboxymethyl or carbamoylmethyl group substituted on the phenyl ring of the phenoxy moiety. Alternate methods of preparation are also provided.
Inventors
- 👤 M Snarey
- 👤 J Wright
- 👤 J Danilewicz
- 👤 J Kemp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:39
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; H; H04; H04N; H04N5/00; H04N5/76; H04N5/91; H04N5/92; H04N5/9201; H04N5/9206; H04N5/9207
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
14 words
A PROPANOLPIPERAZINE COMPOUND SELECTED FROM THE GROUP CONSISTING OF ORGANIC BASES OF THE FORMULA
Claim 2
Dependent Claim
14 words
A PROPANOLPIPERAZINE COMPOUND SELECTED FROM THE GROUP CONSISTING OF ORGANIC BASES OF THE FORMULA
Claim 3
Dependent Claim
12 words
Compound of claim 1 wherein R1 is hydrogen and R3 is chlorophenyl.
Claim 4
Dependent Claim
23 words
Compound of claim 1 wherein R1 is hydrogen and R3 is alkoxyphenyl having from one to six carbon atoms in the alkoxy moiety.
Claim 5
Dependent Claim
33 words
Compound of claim 1 wherein R1 is a straight chain alkyl having from one to six carbon atoms and R3 is alkoxyphenyl having from one to six carbon atoms in the alkoxy moiety.
Claim 6
Dependent Claim
21 words
Compound of claim 1 wherein R(CH2)n is at the 2-position of the phenyl ring, R1 is hydrogen and R3 is 2-methoxyphenyl.
Claim 7
Dependent Claim
21 words
Compound of claim 1 wherein R(CH2)n is at the 4-position of the phenyl ring, R1 is hydrogen and R3 is 2-methoxyphenyl.
Claim 8
Dependent Claim
24 words
Compound of claim 1 wherein R(CH2)n is at the 2-position of the phenyl ring, R1 is methyl at the 4-position and R3 is 2-methoxyphenyl.
Claim 9
Dependent Claim
24 words
Compound of claim 1 wherein R(CH2)n is at the 4-position of the phenyl ring, R1 is methyl at the 2-position and R3 is 2-methoxyphenyl.
Claim 10
Dependent Claim
2 words
1-(2-Carbamoylmethylphenoxy)-3-(4-(2-methoxyphenyl)-piperazin-1-yl)propan-2 -ol.
Claim 11
Dependent Claim
2 words
1-(2-Carbamoylmethylphenoxy)-3-(4-(2-methoxyphenyl)-piperazin-1-yl)propan-2 -ol.
Claim 12
Dependent Claim
2 words
1-(2-Methyl-4-carbamoylmethylphenoxy)-3-(4-(2-methoxyphenyl)piperazin-1 -yl)propan-2-ol.
Claim 13
Dependent Claim
2 words
1-(2-Methyl-4-carbamoylmethylphenoxy)-3-(4-(2-methoxyphenyl)piperazin-1 -yl)propan-2-ol.
References Cited (Backward Citations)
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US3270004A
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US3211735A
Cited
US3277094A
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US3558629A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-23 | 1978-06-24 | 1978-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-23 | 1982-06-24 | 1982-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-23 | 1986-06-24 | 1986-12-24 | $7700.00 | Window Closed / Lapsed |