4-(omega-(4-(2-,or 3-halo-p-tolyl) - 1-piperazinyl) alkoxy) - beta,beta - dimethylhydrocinnamic acid esters
Abstract
Abstract NEWLY SYNTHESIZED 4-(W-(4-(2-, OR 3-HALO P-TOLYL)-1PIPERAZINYL)ALKOXY) - B,B - DIMETHYLHYDROCINNAMIC ACID ESTERS USEFUL FOR CHEMOTHERAPEUTICALLY REDUCING THE NUMBER OF FLUKES OF GENUS SCHISTOSOMA PRESENT IN INFECTED WARM-BLOODED ANIMALS HAVE BEEN FOUND TO ALLEVIATE SYMPTOMS OF SCHISTOSOMIASIS. THESE ESTERS HAVE THE STRUCTURAL FORMULA 1-(R2-OOC-CH2-C(-CH3)2-(R1-1,4-PHENYLENE)-O-(CH2)N-), 4-(X,4-CH3-PHEN-1-YL)-PIPERAZINE WHEREIN X IS A HALOGEN; N IS AN INTEGER OF FROM 3 TO 6; R1 IS HYDROGEN OR LOWER ALKOXY; AND R2 IS METHYL, ETHYL, OR A STRAIGHT OR BRANCHED CHAIN ALKYL RADICAL OF UP TO 5 CARBON ATOMS. THE ESTERS ARE PREPARED BY MICROBIOLOGICALLY OXIDIZING A 1-(2-, OR 3-HALO-P-TOLYL)-4-(W-(P-TERT-PENTYLPHENOXY) ALKYLENE)PIPERAZINE TO THE CORRESPONDING HYDROCINNAMIC ACID AND THEN ESTERIFYING THE ACID.
Inventors
- 👤 Norman E Wideburg
- 👤 Laura H Miller
Bibliographic Details
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