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US3929856A
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US
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1-(3,4-Dimethoxyphenethylamino)-3-(phenoxy)-2-propanols
Assignee: Parke Davis and Co LLC
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Filing: 1974-09-03
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Granted: 1975-12-30
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Expires: 1994-09-03
Abstract
Abstract 1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2propanols; and acid-addition salts. The substituent in the 3(substituted phenoxy) group can be lower alkoxy, chloro, cyano, hydroxymethyl, acetyl, or o-allyl. The compounds are pharmacological agents, especially beta-adrenergic blocking agents with cardio-selective activity. They can be produced by reacting a 1-halo-3-(substituted phenoxy)-2-propanol with 3,4dimethoxyphenethylamine; or by reacting a 1,2-epoxy-3(substituted phenoxy)propane with 3,4-dimethoxyphenethylamine. Starting materials for use in those processes are obtained by reacting a phenol or a sodium phenolate with epichlorohydrin under varying conditions.
Inventors
- 👤 Ann Holmes
- 👤 Robert F Meyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:22
CPC Classifications
C; C07; C07C; C07C217/00; C07C217/02; C07C217/04; C07C217/06; C07C217/14; C07C217/08; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
11 words
A MEMBER OF THE CLASS CONSISTING OF COMPOUNDS OF THE FORMULA
Claim 2
Dependent Claim
11 words
A MEMBER OF THE CLASS CONSISTING OF COMPOUNDS OF THE FORMULA
Claim 3
Dependent Claim
9 words
A compound according to claim 1 which is 1-((3,4-dimethoxyphenethyl)amino)-3-(m-methoxyphenoxy)-2-propanol.
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is 1-(o-chlorophenoxy)-3-((3,4-dimethoxyphenethyl)amino)-2-propanol.
Claim 5
Dependent Claim
9 words
A compound according to claim 1 which is o-(3-((3,4-dimethoxyphenethyl)amino)-2-hydroxypropoxy)benzonitrile.
References Cited (Backward Citations)
US3501769A
Cited
US3459782A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-29 | 1979-06-30 | 1979-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-29 | 1983-06-30 | 1983-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-29 | 1987-06-30 | 1987-12-30 | $7700.00 | Window Closed / Lapsed |