P-Glu-D-Phe-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates

Claim 1

A COMPOUND SELECTED FROM THE GROUP COMSISTING OF L-P-GLU-D-PHE-L-TRP-L-SER-L-TYR-D-ARG-L-LEU-L-ARG-LPRO-GLY-NH2 AND R4-P-GLU-D-PHE-L-TRP-L-SER(R3)-L-TYR(R2)-D-ARG(NGR5)-L-LEU-L-ARG(NG-R1)-L -PRO-GLY-R AND ITS NON-TOXIC SALTS; WHEREIN R IS SELECTED FROM THE CLASS CONSISTING OF NH2, OH, O(LOWER)ALKYL AND O-BENZYL; R1 AND R5 ARE SELECTED FROM THE CLASS CONSISTING HYDROGEN AND A PROTECTING GROUP FOR THE N ,N AND N NITROGEN ATOMS OF ARGININE SELECTED FROM NITRO, TOSYL, BENZYLOXYCARBONYL AND ADAMANTYLOXYCARBONYL; R2 IS SELECTED FORM THE CLASS CONSISTING OF HYDROGEN AND A PROTECTING GROUP FOR THE PHENOLIC HYDROXYL GROUP OF TYROSINE SELECTED FROM TERT-BUTYL, TETRAHYDROPYRANYL, TRITYL, BENZYL, 2,6-DICHLOROBENZYL, BENZYLOXYCARBONYL AND 4BROMOBENZYLOXYCARBONYL; R3 IS SELECTED FROM THE CLASS CONSISTING OF HYDROGEN AND A PROTECTING GROUP FOR THE ALCOHOLIC HYDROXYL GROUP OF SERINE AND IS SELECTED FROM ACETYL, BENZOYL, TETRAHYDROPYRANYL, TERT-BUTYL, TRITYL, 2,6-DICHLOROBENZYL, BENZYL AND BENZYLOXYCARBONYL; R4 IS SELECTED FROM THE CLASS CONSISTING OF HYDROGEN AND AN A-AMINO PROTECTING GROUP, WITH THE PROVISO THAT AT LEAST ONE OF R1, R2, R3 AND R5 IS A PROTECTING GROUP.