Patent US3928601A successfully refreshed from Google Patents.
US3928601A
Expired / Lapsed
US
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Phenoxy-hydroxypropylamines, method and pharmaceutical preparations for treating cardiovascular diseases
Assignee: Hassle AB
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Filing: 1974-01-15
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Granted: 1975-12-23
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Expires: 1994-01-15
Abstract
Abstract Para-substituted phenoxy-hydroxypropylamines having the general formula AND PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ACID ADDITION SALTS THEREOF, WHEREIN R'' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR'''', -SR'''', and -NHCOOR'''', R'''' being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the Beta -receptors of the heart making them useful in treating heart diseases in animals including humans.
Inventors
- 👤 Arne Elof Brandstrom
- 👤 Per Arvid Emil Carlsson
- 👤 Stig Ake Ingemar Carlsson
- 👤 Hans Rudolf Corrodi
- 👤 Lars Ek
- 👤 Bengt Arne-Hjalmar Ablad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 03:00
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138; A61K31/21; A61K31/27; A61P; A61P25/00; A61P25/02; A61P9/00; C; C07; C07C; C07C217/00; C07C217/02; C07C217/04; C07C217/28; C07C217/30; C07C217/32; C07C233/00; C07C233/01; C07C233/16; C07C233/17; C07C233/22; C07C317/00; C07C317/02; C07C317/10; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07D; C07D263/00; C07D263/02; C07D263/08; C07D263/16; C07D263/18; C07D263/20; C07D263/24; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/24; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
36 words
A pharmaceutical preparation for treatment of cardiovascular diseases which comprises as an active ingredient a therapeutically effective dose of at least one para-substituted phenoxy-hydroxypropylamine compound selected from the group consisting of a compound having the formula
Claim 2
Dependent Claim
36 words
A pharmaceutical preparation for treatment of cardiovascular diseases which comprises as an active ingredient a therapeutically effective dose of at least one para-substituted phenoxy-hydroxypropylamine compound selected from the group consisting of a compound having the formula
Claim 3
Dependent Claim
25 words
A pharmaceutical preparation according to claim 1 wherein the active ingredient is a therapeutically effective dose of at least one said compound in racemic form.
Claim 4
Dependent Claim
28 words
A pharmaceutical preparation according to claim 1 wherein the active ingredient is a therapeutically effective dose of at least one said compound as the optically active, dextrorotatary isomer.
Claim 5
Dependent Claim
28 words
A pharmaceutical preparation according to claim 1 wherein the active ingredient is a therapeutically effective dose of at least one said compound as the optically active, levorotatary isomer.
Claim 6
Dependent Claim
21 words
A pharmaceutical preparation according to claim 1 wherein the para-substituted phenoxy-hydroxypropylamine compound comprises 0.1 to 95% by weight of the preparation.
Claim 7
Dependent Claim
31 words
A pharmaceutical preparation according to claim 1 in a form suitable for administration by injection wherein the para-substituted phenoxy-hydroxypropylamine compound comprises about 0.5% to about 20% by weight of the preparation.
Claim 8
Dependent Claim
38 words
A pharmaceutical preparation according to claim 6 for parenteral application which comprises an aqueous solution of a water soluble salt of said para-substituted phenoxy-hydroxy-propylamine compound in an amount of about 0.5 - 10% by weight of the preparation.
Claim 9
Dependent Claim
30 words
A pharmaceutical preparation according to claim 1 in a form suitable for oral administration wherein the para-substituted phenoxy-hydroxypropylamine compound comprises about 0.2% to about 50% by weight of the preparation.
Claim 10
Dependent Claim
24 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 wherein R'' is isopropyl in association with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
24 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 wherein R'' is tertiarybutyl in association with a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
38 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 ( + or - ) -1-isopropylamino -3-(p-( Beta -methoxycarbinylamidoethyl)-phenoxy)-propanol-2 and a pharmaceutically acceptable, non-toxic acid addition salt thereof in association with a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
33 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 (-)-1-isopropylamino -3-(p-( Beta -methoxycarbinYlamidoethyl)-phenoxy)-propanol-2 and a pharmaceutically acceptable, non-toxic acid addition salt thereof in association with a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
32 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 (+)-1-isopropylamino-3-(p-( Beta -methoxycarbinamidoethyl)-phenoxy)-propanol-2 and a pharmaceutically acceptable, non-toxic acid addition salt thereof in association with a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
32 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 1-isopropylamino-3-(p-( gamma -methoxycarbonylamidopropyl)-phenoxy)-propanol-2 and a pharmaceutically acceptable, non-toxic acid addition salt thereof in association with a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
32 words
A pharmaceutical preparation wherein the active ingredient is the compound of claim 1 1-tertiarybutylamino-3-(p-( Beta -methoxycarbinylamidoethyl)-phenoxy)-propanol-2 and a pharmaceutically acceptable, non-toxic acid addition salt thereof in association with a pharmaceutically acceptable carrier.
Claim 17
Independent Claim
34 words
A METHOD FOR TREATING CARDIOVASCULAR DISEASES IN ANIMALS INCLUDING HUMANS WHICH COMPRISES ADMINISTERING A THERAPEUTICALLY EFFECTIVE DOSE OF A PARA-SUBSTITUTED PHENOXYHYDROSYPROPYLAMINE COMPOUND SELECTED FROM THE GROUP CONSISTING ESSENTIALLY OF A COMPOUND HAVING THE FORMULA
Claim 18
Independent Claim
34 words
A METHOD FOR TREATING CARDIOVASCULAR DISEASES IN ANIMALS INCLUDING HUMANS WHICH COMPRISES ADMINISTERING A THERAPEUTICALLY EFFECTIVE DOSE OF A PARA-SUBSTITUTED PHENOXYHYDROSYPROPYLAMINE COMPOUND SELECTED FROM THE GROUP CONSISTING ESSENTIALLY OF A COMPOUND HAVING THE FORMULA
Claim 19
Dependent Claim
30 words
A method for treating cardiovascular diseases in animals including humans, which comprises administering a therapeutically effective dose of a parasubstituted phenoxyhydroxypropylamine compound according to claim 16 wherein R'' is isopropyl.
Claim 20
Dependent Claim
30 words
A method for treating cardiovascular diseases in animals including humans, which comprises administering a therapeutically effective dose of a parasubstituted phenoxyhydroxypropylamine compound according to claim 16 wherein R'' is tertiarybutyl.
References Cited (Backward Citations)
US3712927A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-22 | 1979-06-23 | 1979-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-22 | 1983-06-23 | 1983-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-22 | 1987-06-23 | 1987-12-23 | $7700.00 | Window Closed / Lapsed |