Patent US3928574A successfully refreshed from Google Patents.
US3928574A
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Method and composition for treating diarrhea in mammals
Assignee: Colorado State University Research Foundation
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Filing: 1973-03-27
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Granted: 1975-12-23
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Expires: 1993-03-27
Abstract
Abstract This invention relates to a composition for the treatment of diarrhea in bovine animals which, in addition to the fluid and electrolyte losses sustained by the patient, contains up to as much as twelve times the concentration of potassium normally carried by the blood, glucose and a buffering agent capable of cooperating with the other ingredients to maintain a basic condition such that the pH does not exceed approximately ten, all in a solution that is either hypertonic or isotonic depending upon its method of administration. The solution can be administered intravenously in a concentrated hypertonic form or subcutaneously in a more dilute isotonic or, at most, slightly hypotonic form. The method of treatment varies with the condition of the patient, the critically ill one being given both the I.V. treatment with the solution of higher osmolarity and the subcutaneous treatment with the more dilute isotonic solution at the same time in preference to either one alone, whereas, the less critical patient can be treated with either one and, under most circumstances, just the isotonic solution administered subcutaneously.
Inventors
- 👤 Robert W Phillips
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:46
CPC Classifications
A; A61; A61K; A61K33/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
95 words
A PARENTIAL COMPOSITION FOR USE AS SUPPORTIVE THERAPY IN A TREATMENT FOR DIARRHEA IN BOVINE ANIMALS THAT INCLUDES THE REPLACEMENT OF LOST SODIUM AND CHLORIDE IONS COMPRISING: A BUFFERED BASIC AQUEOUS SOLUTION THAT IS EITHER ISOTONIC OR HYPERTONIC WITH RESPECT TO NORMAL BLOOD, BETWEEN APPROXIMATELY THREE AND TWELVE TIMES THE POTASSIUM ION CONCENTRATION PRESENT IN NORMAL BLOOD, SAID BLOOD NORMALLY HAVING A POTASSIUM ION CONCENTRATION OF ABOUT 5 MEQ./L., AND AN AMOUNT OF GLUCOSE EFFECTIVE AS A SOURCE OF ENERGY AND EFFECTIVE TO ENHANCE THE MOVEMENT OF POTASSIUM INTO THE CELLS THEREBY REPLACING LOST POTASSIUM.
Claim 2
Dependent Claim
95 words
A PARENTIAL COMPOSITION FOR USE AS SUPPORTIVE THERAPY IN A TREATMENT FOR DIARRHEA IN BOVINE ANIMALS THAT INCLUDES THE REPLACEMENT OF LOST SODIUM AND CHLORIDE IONS COMPRISING: A BUFFERED BASIC AQUEOUS SOLUTION THAT IS EITHER ISOTONIC OR HYPERTONIC WITH RESPECT TO NORMAL BLOOD, BETWEEN APPROXIMATELY THREE AND TWELVE TIMES THE POTASSIUM ION CONCENTRATION PRESENT IN NORMAL BLOOD, SAID BLOOD NORMALLY HAVING A POTASSIUM ION CONCENTRATION OF ABOUT 5 MEQ./L., AND AN AMOUNT OF GLUCOSE EFFECTIVE AS A SOURCE OF ENERGY AND EFFECTIVE TO ENHANCE THE MOVEMENT OF POTASSIUM INTO THE CELLS THEREBY REPLACING LOST POTASSIUM.
Claim 3
Dependent Claim
23 words
The composition as set forth in claim 1 in which: the pH is not appreciably less than 7.6 nor substantially greater than 10.
Claim 4
Dependent Claim
20 words
The composition as set forth in claim 1 in which: the potassium concentration is between approximately 15 and 60 meq./L.
Claim 5
Dependent Claim
25 words
The composition as set forth in claim 1 in which: the solution is hypertonic and has an osmolality of between approximately 500 and 1000 mosm./L.
Claim 6
Dependent Claim
27 words
The composition as set forth in claim 1 in which: the solution is hypertonic and includes sufficient sodium hydroxide to bring the pH up to about 10.0.
Claim 7
Dependent Claim
30 words
The composition as set forth in claim 5 in which: the solution contains the equivalent of approximately 5.4 gms./L. of sodium hydroxide and has an osmolality of approximately 1000 mosm./L.
Claim 8
Dependent Claim
26 words
The composition as set forth in claim 1 in which: the solution is buffered with the bicarbonate ion at a concentration of between approximately 50-200 meq./L.
Claim 9
Dependent Claim
16 words
The composition as set forth in claim 7 in which: the buffering agent is sodium bicarbonate.
Claim 10
Dependent Claim
20 words
The composition as set forth in claim 1 in which: the hypertonic solution contains between approximately 5% and 8% glucose.
Claim 11
Dependent Claim
50 words
The dry composition for use dissolved in water to form a parenteral solution to be administered as supportive therapy in the treatment of diarrhea in bovine animals which comprises: approximately 1.7 grams of potassium chloride, 2.0 grams of sodium chloride, 6.8 grams of sodium bicarbonate and 68 grams of glucose.
Claim 12
Dependent Claim
50 words
The dry composition for use dissolved in water to form a parenteral solution to be administered as supportive therapy in the treatment of diarrhea in bovine animals which comprises: approximately 1.7 grams of potassium chloride, 2.0 grams of sodium chloride, 6.8 grams of sodium bicarbonate and 68 grams of glucose.
Claim 13
Dependent Claim
15 words
The dry composition of claim 10 dissolved in enough water to produce an isotonic solution.
Claim 14
Dependent Claim
22 words
The dry composition of claim 10 dissolved in enough water to produce a hypertonic solution having an osmolality greater than 500 mosm./L.
Claim 15
Dependent Claim
21 words
The dry composition as set forth in claim 12 in which the hypertonic solution has an osmolality of approximately 712 mosm./L.
Claim 16
Dependent Claim
16 words
The dry composition as set forth in claim 10 which includes approximately 1.3 grams of MgCl2.6H2O.
Claim 17
Independent Claim
118 words
The method of treating diarrhea in bovine animals which comprises: slowly administering intravenously to a critically ill animal approximately one quart for each sixty pounds of body weight of a buffered basic aqueous solution which is hypertonic with respect to normal blood and which contains sodium and chloride ions at a concentration effective to replace those lost due to dehydration, potassium ions at a concentration amounting to approximately from three to twelve times the potassium concentration in normal bovine blood, said blood normally having a potassium ion concentration of about 5 meq./L., and an amount of glucose effective as a source of energy and effective to enhance the movement of potassium into the cells thereby replacing lost potassium.
Claim 18
Independent Claim
118 words
The method of treating diarrhea in bovine animals which comprises: slowly administering intravenously to a critically ill animal approximately one quart for each sixty pounds of body weight of a buffered basic aqueous solution which is hypertonic with respect to normal blood and which contains sodium and chloride ions at a concentration effective to replace those lost due to dehydration, potassium ions at a concentration amounting to approximately from three to twelve times the potassium concentration in normal bovine blood, said blood normally having a potassium ion concentration of about 5 meq./L., and an amount of glucose effective as a source of energy and effective to enhance the movement of potassium into the cells thereby replacing lost potassium.
Claim 19
Dependent Claim
38 words
The method of treating diarrhea as set forth in claim 15 which includes also administering subcutaneously approximately 2-1/2 quarts for each 60 pounds of body weight the hypertonic solution diluted to the point at which it becomes isotonic.
Claim 20
Independent Claim
131 words
The method of treating diarrhea in bovine animals which comprises: administering subcutaneously to a seriously ill animal approximately 2- 1/2 quarts for each 60 pounds of body weight of a buffered basic aqueous solution which is isotonic with respect to normal blood and which contains sodium and chloride ions at a concentration effective to substantially replace those lost due to dehydration, potassium ions at a concentration amounting to not less than that which is effective to improve the hyperkalemic condition and on up to five times the potassium concentration in normal bovine blood, said blood normally having a potassium ion concentration of about 5 meq./L., and an amount of glucose effective as a source of energy and effective to enhance the movement of potassium into the cells thereby replacing lost potassium.
Claim 21
Independent Claim
131 words
The method of treating diarrhea in bovine animals which comprises: administering subcutaneously to a seriously ill animal approximately 2- 1/2 quarts for each 60 pounds of body weight of a buffered basic aqueous solution which is isotonic with respect to normal blood and which contains sodium and chloride ions at a concentration effective to substantially replace those lost due to dehydration, potassium ions at a concentration amounting to not less than that which is effective to improve the hyperkalemic condition and on up to five times the potassium concentration in normal bovine blood, said blood normally having a potassium ion concentration of about 5 meq./L., and an amount of glucose effective as a source of energy and effective to enhance the movement of potassium into the cells thereby replacing lost potassium.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-22 | 1979-06-23 | 1979-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-22 | 1983-06-23 | 1983-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-22 | 1987-06-23 | 1987-12-23 | $7700.00 | Window Closed / Lapsed |