Patent US3923829A successfully refreshed from Google Patents.
US3923829A
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Preparation of N-(1-ethyl-{60 -pyrrolidylmethyl)-2-methoxy-5-sulfonamidobenzamide
Assignee: Renfag SA
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Filing: 1974-11-19
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Granted: 1975-12-02
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Expires: 1994-11-19
Abstract
Abstract N-(1-ethyl- Alpha -pyrrolidylmethyl)-2-methoxy-5sulfonamidobenzamide is prepared by reacting N-ethyl- Alpha aminomethyl-pyrrolidine with phosphorus oxychloride to give N,N'', N''''-(1-ethyl- Alpha -pyrrolidylmethyl)-phosphoramide which is then reacted with 2-methoxy-5-sulfonamidobenzoic acid.
Inventors
- 👤 Eric Alain Denzler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:12
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; C07D207/09
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
52 words
A PROCESS FOR PREPARING N-(1-ETHYL-A-PYRROLIDYLMETHYL)2-METHOXY-5-SULFONAMIDOBENZAMIDE, COMPRISING THE STEPS OF MIXING N-ETHYL-A-AMINOMETHYL-PYRROLIDINE WITH PHOSPHORUS OXYCHLORIDE IN A SOLVENT SELECTED FROM PYRIDINE AND DIOXANE TO FORM N,N'',N"-(1-ETHYL-A-PYRROLIDYLMETHYL)-PHOSPHORAMIDE, REMOVING THE DIOXANE, IF PRESENT, AND THEN HEATING AT 75* TO 150*C. THE N,N'',N"-(1-ETHYL-A-PYRROLIDYL-METHYL)-PHOSPHORAMIDE WITH 2-METHOXY-5-SULFONAMIDOBENZOIC ACID IN PYRIDINE IN THE PRESENCE OR ABSENCE OF AUTOGENOUS PRESSURE.
Claim 2
Dependent Claim
52 words
A PROCESS FOR PREPARING N-(1-ETHYL-A-PYRROLIDYLMETHYL)2-METHOXY-5-SULFONAMIDOBENZAMIDE, COMPRISING THE STEPS OF MIXING N-ETHYL-A-AMINOMETHYL-PYRROLIDINE WITH PHOSPHORUS OXYCHLORIDE IN A SOLVENT SELECTED FROM PYRIDINE AND DIOXANE TO FORM N,N'',N"-(1-ETHYL-A-PYRROLIDYLMETHYL)-PHOSPHORAMIDE, REMOVING THE DIOXANE, IF PRESENT, AND THEN HEATING AT 75* TO 150*C. THE N,N'',N"-(1-ETHYL-A-PYRROLIDYL-METHYL)-PHOSPHORAMIDE WITH 2-METHOXY-5-SULFONAMIDOBENZOIC ACID IN PYRIDINE IN THE PRESENCE OR ABSENCE OF AUTOGENOUS PRESSURE.
Claim 3
Dependent Claim
41 words
A process according to claim 1, in which the reaction of N-ethyl- Alpha -aminomethyl-pyrrolidine with phosphorus oxychloride is carried out in dioxane and the N,N'' ,N''''-(1-ethyl- Alpha -pyrrolidylmethyl)-phosphoramide is isolated in the form of a mixture of di- and tri- hydrochlorides.
References Cited (Backward Citations)
US3723416A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-01 | 1979-06-02 | 1979-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-01 | 1983-06-02 | 1983-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-01 | 1987-06-02 | 1987-12-02 | $7700.00 | Window Closed / Lapsed |