US3917830A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Steroidal anaesthetic composition for intraveneous injection
Assignee: Glaxo Laboratories Ltd
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Filing: 1972-06-15
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Granted: 1975-11-04
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Expires: 1992-06-15
Abstract
Abstract A composition for use by injection as an anaesthetic comprising 3 Alpha -hydroxy 5 Alpha - pregnane - 11,20 dione in solution in an inert organic liquid medium. The composition may be in the form of a solution which also contains water, a non-aqueous solution or an emulsion or microemulsion. The emulsions and microemulsions are preferably of the oil-in-water type. Water-miscible substances which may be used as or in the liquid medium include polyhydroxy alcohols and water-soluble esters and amides. Other substances which may be used as the liquid medium include oils, long chain alcohols and esters, and fatty acid esters.
Inventors
- 👤 Derek Roger Pearce
- 👤 Benjamin Davis
- 👤 Paul Connor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 06:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
101 words
A COMPOSITION ADAPTED FOR USE IN MEDICINE BY INTRAVENOUS INJECTION AS AN ANAESTHETIC COMPRISING 3A-HYDROXY-5APREGNANE-11,20-DIONE IN SOLUTION IN AN INERT LIQUID INJECTION MEDIUM CONSISTING ESSENTIALLY OF A SOLUTION OF WATER IN AN ORGANIC LIQUID SELECTED FROM THE GROUP CONSISTING OF A POLYHYDRIC ALCOHOL HAVING 2 OR 3 HYDROXY GROUPS AND 1-6 CARBON ATOMS AND A WATER SOLUTION ESTER OF AN A-HYDROXY CARBOXYLIC ACID AND AN ALKANOL HAVING 1-6 CARBON ATOMS IN WHICH THE ORGANIC LIQUID CONSTITUTES MORE THAN 50% OF THE TOTAL INJECTION MEDIUM, SAID COMPOSITION BEING IN UNIT DOSAGE FORM, EACH DOSAGE CONTAINING 10 TO 300 MG OF THE 3A-HYDROXY-5A-PREGNANE-11,20-DIONE.
Claim 2
Dependent Claim
101 words
A COMPOSITION ADAPTED FOR USE IN MEDICINE BY INTRAVENOUS INJECTION AS AN ANAESTHETIC COMPRISING 3A-HYDROXY-5APREGNANE-11,20-DIONE IN SOLUTION IN AN INERT LIQUID INJECTION MEDIUM CONSISTING ESSENTIALLY OF A SOLUTION OF WATER IN AN ORGANIC LIQUID SELECTED FROM THE GROUP CONSISTING OF A POLYHYDRIC ALCOHOL HAVING 2 OR 3 HYDROXY GROUPS AND 1-6 CARBON ATOMS AND A WATER SOLUTION ESTER OF AN A-HYDROXY CARBOXYLIC ACID AND AN ALKANOL HAVING 1-6 CARBON ATOMS IN WHICH THE ORGANIC LIQUID CONSTITUTES MORE THAN 50% OF THE TOTAL INJECTION MEDIUM, SAID COMPOSITION BEING IN UNIT DOSAGE FORM, EACH DOSAGE CONTAINING 10 TO 300 MG OF THE 3A-HYDROXY-5A-PREGNANE-11,20-DIONE.
Claim 3
Dependent Claim
19 words
A composition as claimed in claim 1 wherein the liquid injection medium comprises propylene glycol, glycerol or glycerol formal.
Claim 4
Dependent Claim
22 words
A composition as claimed in claim 1 wherein 3 Alpha -hydroxy-5 Alpha -pregnane-11,20-dione is present in an amount of 0.1-4% by weight.
Claim 5
Dependent Claim
20 words
A method of inducing anaesthesia which method comprises intravenously administering to a subject a composition as claimed in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |