Patent US3915947A successfully refreshed from Google Patents.
US3915947A
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Des-{8 His{hu 2{b ,Gly{hu 10{b {9 -D-Ala{hu 6 {b LHRH ethylamide as an inhibitor of LHRH
Assignee: Eli Lilly and Co
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Filing: 1974-07-11
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Granted: 1975-10-28
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Expires: 1994-07-11
Abstract
Abstract A compound of the formula PyroGlu-Trp-Ser-Tyr-D-Ala-Leu-Arg-ProNHCH2CH3 as well as its pharmaceutically acceptable acid addition salts exhibit inhibiting action toward luteinizing hormone release hormone (LH-RH) and are potent contraceptives.
Inventors
- 👤 James E Shields
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:55
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
6 words
A COMPOUND OF THE FORMULA L-PYROGLU-L-TRP-L-SER-L-TYR-D-ALA-L-LEU-L-ARG-L-PRO-
Claim 2
Dependent Claim
6 words
A COMPOUND OF THE FORMULA L-PYROGLU-L-TRP-L-SER-L-TYR-D-ALA-L-LEU-L-ARG-L-PRO-
Claim 3
Dependent Claim
36 words
A compound of the formula R3-L-Trp-L-(Bzl)Ser-L-(R2)Tyr-D-Ala-L-Leu-L-(R)Arg-L-Pro-NHCH2CH3 in which R is nitro or tosyl; R2 is benzyl or 2,5-dichlorobenzyl; and R3 is H-, tert-BOC-, PMBOC-, BPOC-, or R4 -L-PyroGlu- in which R4 is H-, CBz-, or PMBOC-.
Claim 4
Dependent Claim
36 words
A compound of the formula R3-L-Trp-L-(Bzl)Ser-L-(R2)Tyr-D-Ala-L-Leu-L-(R)Arg-L-Pro-NHCH2CH3 in which R is nitro or tosyl; R2 is benzyl or 2,5-dichlorobenzyl; and R3 is H-, tert-BOC-, PMBOC-, BPOC-, or R4 -L-PyroGlu- in which R4 is H-, CBz-, or PMBOC-.
Claim 5
Dependent Claim
20 words
A compound of claim 2, in which R is nitro; R2 is benzyl; and R3 is H-, tert-BOC-, or CBz-L-PyroGlu-.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-27 | 1979-04-28 | 1979-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-27 | 1983-04-28 | 1983-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-27 | 1987-04-28 | 1987-10-28 | $7700.00 | Window Closed / Lapsed |