US3911111A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enzyme inhibitor specific against thiol protease and process for production thereof
Assignee: Taisho Pharmaceutical Co Ltd
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Filing: 1974-02-28
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Granted: 1975-10-07
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Expires: 1994-02-28
Abstract
Abstract A new specific enzyme inhibitor, E-64, possessing a specific inhibitive activity against only thiol proteases together with extremely low toxicity is obtained by culturing an E-64 producing microorganism of the Aspergillus japonicus group in a nutrient medium therefor.
Inventors
- 👤 Jiro Sawada
- 👤 Tetsuo Misaki
- 👤 Kazunori Hanada
- 👤 Masaharu Tamai
- 👤 Michio Yamagishi
- 👤 Hikoji Tsuji
- 👤 Kyoko Komiya
- 👤 Takako Nakajima
- 👤 Junichi Machida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:34
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/005; A61P; A61P29/00; C; C07; C07D; C07D303/00; C07D303/02; C07D303/48; C12; C12N; C12N1/00; C12N1/14; C12N1/145; C12P; C12P1/00; C12P1/02; C12R; C12R2001/00; C12R2001/645; C12R2001/66; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/913
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
57 words
A process for production of E-64 which comprises cultivating the microorganism strain Aspergillus japonicus TPR-64 (ATCC No. 20397) on a solid culture medium containing wheat bran, rice hull and water until E-64 is produced in said medium, extracting so-produced E-64 from the cultivating medium with water or an organic solvent and separating E-64 from the extracting solution.
Claim 2
Dependent Claim
29 words
A process according to claim 2 wherein E-64 is separated from the extracted solution by the combination of the column chromatography of ion exchange resins, ion exchangers and adsorbents.
References Cited (Backward Citations)
US3819486A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-06 | 1979-04-07 | 1979-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-06 | 1983-04-07 | 1983-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-06 | 1987-04-07 | 1987-10-07 | $7700.00 | Window Closed / Lapsed |