US3910885A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Alkoxy nucleosides and intermediates therefore
Assignee: Syntex USA LLC
•
Filing: 1974-03-12
•
Granted: 1975-10-07
•
Expires: 1994-03-12
Abstract
Abstract Novel 4''-Alkoxy- Beta -D-ribofuranosyl, 4''-alkoxy-2''-deoxyBeta -D-erythro-pentofuranosyl and 4''-alkoxy- Beta -Darabinofuranoxyl nucleosides and the corresponding 4''-haloalkoxy nucleosides can be prepared from the respective 4''-alkoxy-5''deoxy-5''-iodo- Beta -D-ribofuranosyl, 4''-alkoxy-2'', 5''-dideoxy5''-iodo- Beta -D-erythropentofuranosyl and 4''-alkoxy-5''-deoxy5''-iodo- Beta -D-arabinofuranosyl nucleosides. The novel 4''-alkoxy and 4''-haloalkoxy nucleosides are valuable pharmacological agents. For example, they are useful in regulating and controlling metabolism and for producting metabolic deficiencies in biological systems.
Inventors
- 👤 John G Moffatt
- 👤 Julien P H Verheyden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:40
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/16
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
12 words
A COMPOUND SELECTED FROM THE GROUP OF COMPOUNDS REPRESENTED BY THE FORMULA:
Claim 2
Dependent Claim
12 words
A COMPOUND SELECTED FROM THE GROUP OF COMPOUNDS REPRESENTED BY THE FORMULA:
Claim 3
Dependent Claim
9 words
A compound of claim 1 wherein R is methyl.
Claim 4
Dependent Claim
11 words
A compound of claim 2 wherein B is a pyrimidine base.
Claim 5
Dependent Claim
8 words
The compound of claim 3 which is 4''-methoxy-uridine.
Claim 6
Dependent Claim
8 words
The compound of claim 3 which is 4''-methoxy-cytidine.
Claim 7
Dependent Claim
12 words
The compound of claim 3 wherein B is 5-fluorouracil-1-yl; 1-(2-deoxy-4-methoxy- Beta -D-erythro-pentofuranosyl)-5-fluorouracil.
Claim 8
Dependent Claim
13 words
The compound of claim 3 wherein B is cytosin-1-yl; 1-(4-methoxy- Beta -D-arabinofuranosyl) cytosine.
Claim 9
Dependent Claim
24 words
The compound of claim 3 wherein B is a hydrolyzable benzoyl derivative of a pyrimidine base and R4, R5 and R6 are benzoyl groups.
Claim 10
Dependent Claim
8 words
The compound of claim 8 which is N4-benzoyl-1-(2,3,5-tri-O-benzoyl-4-methoxy)cytidine.
Claim 11
Dependent Claim
10 words
The compound of claim 8 which is N4-benzoyl-1-(2,3,5-tri-O-benzoyl-4-methoxy- Beta -D-arabinofuranosyl)cytosine.
Claim 12
Dependent Claim
10 words
The compound of claim 8 which is N4-benzoyl-1-(2,3,5-tri-O-benzoyl-4-methoxy- Beta -D-arabinofuranosyl)-5-fluorocytosine.
Claim 13
Dependent Claim
11 words
A compound of claim 2 wherein B is a purine base.
Claim 14
Dependent Claim
10 words
The compound of claim 12 wherein B is 8-aza-9-deazaadmin-9-yl; 4''-methoxy-8-aza-9-deazaadenosine.
Claim 15
Dependent Claim
10 words
The compound of claim 12 wherein B is 2-fluoroadenin-9-yl; 4''-methoxy-2-fluoroadenosine.
Claim 16
Dependent Claim
8 words
The compound of claim 12 which is 4''-methoxy-adenosine.
Claim 17
Dependent Claim
10 words
The compound of claim 12 wherein B is N6-dimethyladenin-9-yl; N6-dimethyl-4''-methoxy-adenosine.
Claim 18
Dependent Claim
13 words
The compound of claim 12 wherein B is adenin-9-yl; 9-(4-methoxy- Beta -D-arabinofuranosyl) adenine.
Claim 19
Dependent Claim
25 words
The compound of claim 12 in which B is a hydrolyzable benzoyl derivative of a purine base and R4, R5 and R6 are benzoyl groups.
Claim 20
Dependent Claim
10 words
The compound of claim 10 which is N6-benzoyl-9-(2,3,5-tri-O-benzoyl-4-methoxy- Beta -D-Arabinofuranosyl)adenine.
Claim 21
Dependent Claim
10 words
A compound selected from the group represented by the formula
Claim 22
Dependent Claim
10 words
A compound selected from the group represented by the formula
References Cited (Backward Citations)
US3585189A
Cited
US3817978A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-06 | 1979-04-07 | 1979-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-06 | 1983-04-07 | 1983-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-06 | 1987-04-07 | 1987-10-07 | $7700.00 | Window Closed / Lapsed |