Patent US3908014A successfully refreshed from Google Patents.
US3908014A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions and methods of inhibiting histamine activity with thiourea derivatives
Assignee: Smith Kline & French Laboratories Ltd
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Filing: 1973-12-26
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Granted: 1975-09-23
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Expires: 1993-12-26
Abstract
Abstract Pharmaceutical compositions and methods of inhibiting histamine activity with N-heterocyclic-alkylthioureas.
Inventors
- 👤 Graham John Durant
- 👤 John Colin Emmett
- 👤 Charon Robin Ganellin
- 👤 George Raymond White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:07
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D233/00; C07D233/54; C07D233/66; C07D233/68; C07D233/84; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
48 words
A PHARMACEUTICAL COMPOSITION TO INHIBIT H-2 HISTAMINE RECEPTORS, SAID H-2 HISTAMINE RECEPTORS BEING THOSE HISTAMINE RECPTORS WHICH ARE NOT INHIBITED BY MEPYRAMINE BUT ARE INHIBITED BY BURIMAMIDE, COMPRISING A PHARMACEUTICAL CARRIER AND, IN AN EFFECTIVE AMOUNT TO INHIBIT SAID H-2 HISTAMINE RECEPTORS, A THIOUREA COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
48 words
A PHARMACEUTICAL COMPOSITION TO INHIBIT H-2 HISTAMINE RECEPTORS, SAID H-2 HISTAMINE RECEPTORS BEING THOSE HISTAMINE RECPTORS WHICH ARE NOT INHIBITED BY MEPYRAMINE BUT ARE INHIBITED BY BURIMAMIDE, COMPRISING A PHARMACEUTICAL CARRIER AND, IN AN EFFECTIVE AMOUNT TO INHIBIT SAID H-2 HISTAMINE RECEPTORS, A THIOUREA COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
14 words
A pharmaceutical composition according to claim 1 in which tHe thiourea compound is N-methyl-N''-(4-(2-thiazolyl)-butyl)thiourea.
Claim 4
Dependent Claim
14 words
A pharmaceutical composition according to claim 1 in which the thiourea compound is N-methyl-N''-(4-(3-(1,2,4-triazolyl))butyl)thiourea.
Claim 5
Dependent Claim
14 words
A pharmaceutical composition according to claim 1 in which the thiourea compound is N-methyl-N''-(4-(2-pyridyl)-butyl)thiourea.
Claim 6
Independent Claim
57 words
A method of inhibiting H-2 histamine receptors, said H-2 histamine receptors being those histamine receptors which are not inhibited by mepyramine but are inhibited by burimamide, which comprises administering to an animal in need of inhibition of said H-2 histamine receptors in an amount sufficient to inhibit said H-2 histamine receptors a thiourea compound of the formula:
Claim 7
Independent Claim
57 words
A method of inhibiting H-2 histamine receptors, said H-2 histamine receptors being those histamine receptors which are not inhibited by mepyramine but are inhibited by burimamide, which comprises administering to an animal in need of inhibition of said H-2 histamine receptors in an amount sufficient to inhibit said H-2 histamine receptors a thiourea compound of the formula:
Claim 8
Dependent Claim
13 words
A method according to claim 5 in which the thiourea compound is N-methyl-N''-(4-(3-(1,2,4-triazolyl))butyl)-thiourea.
Claim 9
Dependent Claim
13 words
A method according to claim 5 in which the thiourea compound is N-methyl-N''-(4-(2-pyridyl)butyl)thiourea.
Claim 10
Dependent Claim
13 words
A method according to claim 5 in which the thiourea compound is N-methyl-N''-(4-(2-thiazolyl)butyl)thiourea.
Claim 11
Independent Claim
37 words
A method of inhibiting gastric acid secretion which comprises administering internally to an animal in need of inhibition of gastric acid secretion in an amount sufficient to inhibit gastric acid secretion a thiourea compound of the formula:
Claim 12
Independent Claim
37 words
A method of inhibiting gastric acid secretion which comprises administering internally to an animal in need of inhibition of gastric acid secretion in an amount sufficient to inhibit gastric acid secretion a thiourea compound of the formula:
Claim 13
Independent Claim
31 words
A method of producing anti-inflammatory activity which comprises administering to an animal in need of said activity in an amount sufficient to produce said activity a thiourea compound of the formula:
Claim 14
Independent Claim
31 words
A method of producing anti-inflammatory activity which comprises administering to an animal in need of said activity in an amount sufficient to produce said activity a thiourea compound of the formula:
References Cited (Backward Citations)
US3558640A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-22 | 1979-03-24 | 1979-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-22 | 1983-03-24 | 1983-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-22 | 1987-03-24 | 1987-09-23 | $7700.00 | Window Closed / Lapsed |