Patent US3908003A successfully refreshed from Google Patents.
US3908003A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enrobed solid hydrophobic tableting lubricants and compositions
Assignee: Wyeth LLC
•
Filing: 1974-03-07
•
Granted: 1975-09-23
•
Expires: 1994-03-07
Abstract
Abstract Conventional solid hydrophobic tableting lubricants enrobed in a hydrophilic friable sheath are disclosed. The utilization of these enrobed lubricants with conventional tableting equipment makes possible the preparation of compacted tablets with improved dissolution times.
Inventors
- 👤 Marvin Hersh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2009
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
108 words
A TABLETING LUBRICANT COMPOSITION CONSISTING ESSENTIALLY OF MICROPELLETS OF FINELY DIVIDED PARTICLES OF SOLID HYDROPHOBIC TABLETING LUBRICANT SELECTED FROM THE GROUP CONSISTING OF MAGNESIUM STREARATE CALCIUM STEARATE STERARIC ACID TALCUM AND POWDERED VEGETABLE STEARINE A SUBSTANTIAL PROPORTON OF THE PARTICLES OF SAID LUBRICANT BEING ENROBED IN A HYDROPHILIC FRIABLE SHEATH SAID SHEATHING MATERIAL BEING SELECTED FROM THE GROUP CONSISTING OF MANNITOL POLYETHYLENE GLYCOL 4,000 6,000 AND 20,000 GELATIN METHYL CELLULOSE CARBOXYMETHYLCELLULOSE GUM, ARABIC AND POLYVINYL ALCOHOL SAID ENROBED TABLETING LUBRICANT IMPARTING A REDUCTION IN DISSOLUTION TIME TO A COMPACTED PHARMACEUTICAL DOSAGE FORM WHEN INCORPORATED IN SAID COMPACTED PHARMACEUTICAL DOSAGE FORM AS COMPARED TO SAID LUBRICANT WHEN NOT ENROBED.
Claim 2
Dependent Claim
108 words
A TABLETING LUBRICANT COMPOSITION CONSISTING ESSENTIALLY OF MICROPELLETS OF FINELY DIVIDED PARTICLES OF SOLID HYDROPHOBIC TABLETING LUBRICANT SELECTED FROM THE GROUP CONSISTING OF MAGNESIUM STREARATE CALCIUM STEARATE STERARIC ACID TALCUM AND POWDERED VEGETABLE STEARINE A SUBSTANTIAL PROPORTON OF THE PARTICLES OF SAID LUBRICANT BEING ENROBED IN A HYDROPHILIC FRIABLE SHEATH SAID SHEATHING MATERIAL BEING SELECTED FROM THE GROUP CONSISTING OF MANNITOL POLYETHYLENE GLYCOL 4,000 6,000 AND 20,000 GELATIN METHYL CELLULOSE CARBOXYMETHYLCELLULOSE GUM, ARABIC AND POLYVINYL ALCOHOL SAID ENROBED TABLETING LUBRICANT IMPARTING A REDUCTION IN DISSOLUTION TIME TO A COMPACTED PHARMACEUTICAL DOSAGE FORM WHEN INCORPORATED IN SAID COMPACTED PHARMACEUTICAL DOSAGE FORM AS COMPARED TO SAID LUBRICANT WHEN NOT ENROBED.
Claim 3
Dependent Claim
24 words
The composition of claim 1 wherein the solid hydrophobic tableting lubricant is magnesium stearate and the hydrophilic friable sheathing material is polyethylene glycol 4000.
Claim 4
Dependent Claim
22 words
The composition of claim 1 wherein the solid hydrophobic tableting lubricant is magnesium stearate and the hydrophilic friable sheathing material is gelatin.
Claim 5
Dependent Claim
22 words
The composition of claim 1 wherein the solid hydrophobic tableting lubricant is calcium stearate and the hydrophilic friable sheathing material is gelatin.
Claim 6
Dependent Claim
23 words
The composition of claim 1 wherein the solid hydrophobic tableting lubricant is talc and the hydrophilic friable sheathing material is polyethylene glycol 6,000.
Claim 7
Dependent Claim
103 words
A compressed pharmaceutical medicament tablet containing as tableting lubricant a tableting lubricant composition consisting essentially of micropellets of finely divided particles of solid hydrophobic tableting lubricant selected from the group consisting of magnesium stearate, calcium stearate, stearic acid, talcum, and powdered vegetable stearine, a substantial proportion of the particles of said lubricant being enrobed in a hydrophilic friable sheath, said sheathing material being selected from the group consisting of mannitol, polyethylene glycol 4,000, 6,000, and 20,000, gelatin, methyl cellulose, carboxymethylcellulose, gum arabic, and polyvinyl alcohol; said tablet having imparted, by said enrobed lubricant, redUced disintegration time compared to said lubricant if not enrobed.
Claim 8
Dependent Claim
103 words
A compressed pharmaceutical medicament tablet containing as tableting lubricant a tableting lubricant composition consisting essentially of micropellets of finely divided particles of solid hydrophobic tableting lubricant selected from the group consisting of magnesium stearate, calcium stearate, stearic acid, talcum, and powdered vegetable stearine, a substantial proportion of the particles of said lubricant being enrobed in a hydrophilic friable sheath, said sheathing material being selected from the group consisting of mannitol, polyethylene glycol 4,000, 6,000, and 20,000, gelatin, methyl cellulose, carboxymethylcellulose, gum arabic, and polyvinyl alcohol; said tablet having imparted, by said enrobed lubricant, redUced disintegration time compared to said lubricant if not enrobed.
References Cited (Backward Citations)
US3210208A
Cited
US3382150A
Cited
US3518344A
Cited
US3518343A
Cited
US3518345A
Cited
US3619462A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-22 | 1979-03-24 | 1979-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-22 | 1983-03-24 | 1983-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-22 | 1987-03-24 | 1987-09-23 | $7700.00 | Window Closed / Lapsed |