Patent US3907986A successfully refreshed from Google Patents.
US3907986A
Expired / Lapsed
US
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Live attenuated infectious bovine rhinotracheitis virus vaccines and preparation thereof
Assignee: Recherche et Industrie Therapeutiques
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Filing: 1972-12-18
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Granted: 1975-09-23
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Expires: 1992-12-18
Abstract
Abstract Genetically stable non-pathogenic strains of infectious bovine rhinotracheitis virus are obtained by combination of (a) induction and isolation of temperature-sensitive mutant strains and (b) serial passages (of the obtained temperature-sensitive strains) in heterologous cell cultures. The obtained virus strains are useful for vaccine production.
Inventors
- 👤 Nathan Zygraich
- 👤 Michele Lobmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:27
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/01; A; A61; A61K; A61K39/00; A61K39/12; A61K39/245; A61K39/265; A61K2039/51; A61K2039/525; A61K2039/5254; A61K2039/55; A61K2039/552; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16711; C12N2710/16734; Y; Y10; Y10S; Y10S424/00; Y10S424/813; Y10S424/821
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
64 words
A LIVE VIRUS INFECTIOUS BOVINE RHINOTRACHEITIS VACCINE COMPRISING AN EFFECTIVE DOSE OF AT LEAST 104.2 TCID50 OF A TEMPERATURE-SENSITIVE NITROUS ACID MUTANT OF A PATHOGENIC INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS CAPABLE OF CAUSING ABORTION IN PREGNANT COWS, SAID MUTANT BEING ABLE TO MULTIPLY LOCALLY IN THE UPPER RESPIRATORY TRACT OF A BOVINE ANIMAL WITHOUT SIGNIFICANT VIRUS MULTIPLICATION IN WARMER INTERNAL ORGANS, AND A PHARCEUTICAL DILUENT.
Claim 2
Dependent Claim
64 words
A LIVE VIRUS INFECTIOUS BOVINE RHINOTRACHEITIS VACCINE COMPRISING AN EFFECTIVE DOSE OF AT LEAST 104.2 TCID50 OF A TEMPERATURE-SENSITIVE NITROUS ACID MUTANT OF A PATHOGENIC INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS CAPABLE OF CAUSING ABORTION IN PREGNANT COWS, SAID MUTANT BEING ABLE TO MULTIPLY LOCALLY IN THE UPPER RESPIRATORY TRACT OF A BOVINE ANIMAL WITHOUT SIGNIFICANT VIRUS MULTIPLICATION IN WARMER INTERNAL ORGANS, AND A PHARCEUTICAL DILUENT.
Claim 3
Dependent Claim
13 words
A vaccine according to claim 1 in a form suitable for intranasal administration.
Claim 4
Dependent Claim
15 words
A vaccine according to claim 2, in which the dose is at least 105.2 TCID50.
Claim 5
Dependent Claim
12 words
A vaccine according to claim 1, in which the vaccine is freeze-dried.
Claim 6
Dependent Claim
31 words
A process of immunizing a susceptible cow against infectious bovine rhinotracheitis comprising administering to said cow an effective dose of at least 104.2 TCID50 of a vaccine according to claim 1.
Claim 7
Dependent Claim
14 words
A process as claimed in claim 5, where the route of administration is intranasal.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-22 | 1979-03-24 | 1979-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-22 | 1983-03-24 | 1983-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-22 | 1987-03-24 | 1987-09-23 | $7700.00 | Window Closed / Lapsed |