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US3906108A
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Stabilized tretinoin cream emulsion
Assignee: Johnson and Johnson
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Filing: 1973-10-12
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Granted: 1975-09-16
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Expires: 1993-10-12
Abstract
Abstract A stabilized cream emulsion of tretinoin, capable of being stored without refrigeration for long periods of time without losing therapeutic effectiveness and while maintaining the uniformity and stability of the cream, contains xanthan gum as the stabilizer.
Inventors
- 👤 Lanny G Felty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 13:37
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/20; A61K8/00; A61K8/18; A61K8/30; A61K8/67; A61K8/671; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P17/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
151 words
IN A TRETINOIN CREAM EMULSION FOR TROPICAL APPLICATION COMPRISING FROM ABOUT 0.005 TO ABOUT 0.5% BY WEIGHT OF TRETINOIN, FROM ABOUT 1.0 TO ABOUT 10.0% BY WEIGHT OF AN EMULSIFIER, FROM ABOUT 15.0 TO ABOUT 50.0% BY WEIGHT OF A HYDROPHOBIC MATERIAL SELECTED FROM THE GROUP CONSISTING OF PETROLATUM, BEESWAX, SPERM WAX, LANOLIN, MINERAL OIL, THE LIQUID AND SOLID FATTY ACIDS HAVING FROM ABOUT 12 TO ABOUT 20 CARBON ATOM , FATTY ALCOHOLS HAVING FROM ABOUT 12 TO ABOUT 20 CARBON ATOMS, AND FATTY ACID ESTER WHEREIN THE FATTY ACID MOIRTY HAS FROM ABOUT 12 TO ABOUT 20 CARBON ATOMS, FROM ABOUT 0.05 TO ABOUT 1.0% BY WEIGHT OF A PRESERVATIVE, FROM ABOUT 0.01 TO ABOUT 1.0% BY WEIGHT OF AN ANTIOXIDANT, AND WATER, THE IMPROVEMENT WHICH COMPRISES ALSO HAVING THEREIN AS A STABILIZER TO PREVENT BREAKING OF THE EMULSION, FROM ABOUT 0.1 TO ABOUT 1.0% BY WEIGHT OF XANTHAN GUM.
Claim 2
Dependent Claim
151 words
IN A TRETINOIN CREAM EMULSION FOR TROPICAL APPLICATION COMPRISING FROM ABOUT 0.005 TO ABOUT 0.5% BY WEIGHT OF TRETINOIN, FROM ABOUT 1.0 TO ABOUT 10.0% BY WEIGHT OF AN EMULSIFIER, FROM ABOUT 15.0 TO ABOUT 50.0% BY WEIGHT OF A HYDROPHOBIC MATERIAL SELECTED FROM THE GROUP CONSISTING OF PETROLATUM, BEESWAX, SPERM WAX, LANOLIN, MINERAL OIL, THE LIQUID AND SOLID FATTY ACIDS HAVING FROM ABOUT 12 TO ABOUT 20 CARBON ATOM , FATTY ALCOHOLS HAVING FROM ABOUT 12 TO ABOUT 20 CARBON ATOMS, AND FATTY ACID ESTER WHEREIN THE FATTY ACID MOIRTY HAS FROM ABOUT 12 TO ABOUT 20 CARBON ATOMS, FROM ABOUT 0.05 TO ABOUT 1.0% BY WEIGHT OF A PRESERVATIVE, FROM ABOUT 0.01 TO ABOUT 1.0% BY WEIGHT OF AN ANTIOXIDANT, AND WATER, THE IMPROVEMENT WHICH COMPRISES ALSO HAVING THEREIN AS A STABILIZER TO PREVENT BREAKING OF THE EMULSION, FROM ABOUT 0.1 TO ABOUT 1.0% BY WEIGHT OF XANTHAN GUM.
Claim 3
Dependent Claim
12 words
The product of claim 1 wherein the emulsifier is a non-ionic emulsifier.
Claim 4
Dependent Claim
18 words
The product of claim 1 which contains from about 0.3 to about 0.5% by weight of xanthan gum.
Claim 5
Dependent Claim
39 words
The product of claim 2 wherein the emulsifier is selected from the group consisting of polyoxyethylene 25 oxypropylene stearate, polyoxyl 40 stearate, polyethylene glycol 400 monostearate, polyethylene glycol 600 monostearate, polyoxyethylene 20 stearyl ether and polyoxyethylene 2 stearyl ether.
Claim 6
Dependent Claim
11 words
The product of claim 1 wherein the preservative is sorbic acid.
Claim 7
Dependent Claim
22 words
The product of claim 1 wherein the antioxidant is a member selected from the group consisting of butylated hydroxytoluene, and dl-alpha tocopherol.
Claim 8
Dependent Claim
35 words
The product of claim 1 wherein the hydrophobic material is selected from the group consisting of a stearyl alcohol, petrolatum, stearic acid, isopropyl myristate, cetyl alcohol, beeswax, sperm wax, lanolin, mineral oil and glyceryl monostearate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-15 | 1979-03-17 | 1979-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-15 | 1983-03-17 | 1983-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-15 | 1987-03-17 | 1987-09-16 | $7700.00 | Window Closed / Lapsed |