Abstract This invention is directed toward novel central nervous system depressants of the formula: wherein R1 is a member selected from the group consisting of the hydrogen, lower alkyl, benzyl and lower alkoxyalkyl radicals; R2 is a member selected from the group consisting of the lower alkyl, phenyl and benzyl radicals; R3 is a member selected from the group consisting of hydrogen, an alkali metal cation, an alkaline earth metal cation, the ammonium cation, a tri(lower)alkyl ammonium cation, the pyridinum ion, a lower alkyl radical and an aralkyl radical of 7 to 9 carbon atoms; X is a member selected from the group consisting of the halo, cyano, trifluoromethyl, nitro and lower alkylthio radicals; Y is a member selected from the group consisting of the hydrogen, halo, trifluoromethyl, nitro and lower alkylthio radicals; and the pharmaceutically acceptable N- acid addition salts thereof. This invention also provides methods for the preparation of the central nervous system depressant compounds and their administration as well as the compositions for administration which contain the active compounds of this invention.
A PROCESS FOR INCLUDING A CALMING EFFECT IN A WARMBLODDED ANIMAL WHICH COMPRISES ADMINISTRATING SAID ANIMAL AN EFFECTIVE AMOUNT OF A PHARMACEUTICAL COMPOSITION CONTAINING AS THE ESSENTIAL ACTIVE INGREDIENT A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
34 words
A PROCESS FOR INCLUDING A CALMING EFFECT IN A WARMBLODDED ANIMAL WHICH COMPRISES ADMINISTRATING SAID ANIMAL AN EFFECTIVE AMOUNT OF A PHARMACEUTICAL COMPOSITION CONTAINING AS THE ESSENTIAL ACTIVE INGREDIENT A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
18 words
The process of claim 1 in which said active ingredient is a methane sulfonate salt of 7-chloro-5-(o-chlorophenyl-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, N-carbomethoxymethyl-N-methylglycinate.
Claim 4
Dependent Claim
19 words
The process of claim 1 in which said active ingredient is an alkali metal salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2 -one, N-carboxymethyl-N-methylglycinate.
Claim 5
Dependent Claim
24 words
A composition of matter for inducing a calming effect in a warm-blooded animal comprising as the essential active ingredient, a compound of the formula:
Claim 6
Dependent Claim
24 words
A composition of matter for inducing a calming effect in a warm-blooded animal comprising as the essential active ingredient, a compound of the formula:
Claim 7
Dependent Claim
19 words
The composition of claim 4 in which said active ingredient is an alkali metal salt of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H,-1,4-benzodiazepin-2 -one, N-carboxymethyl-N-methylglycinate.