Patent US3903067A successfully refreshed from Google Patents.
US3903067A
Expired / Lapsed
US
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Allergenic extracts reacted with epihalohydrins
Assignee: Beecham Group PLC
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Filing: 1973-07-20
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Granted: 1975-09-02
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Expires: 1993-07-20
Abstract
Abstract Desensitizing or immunizing agents are provided for treating hypersensitive or allergic conditions. Modified allergenic material is prepared comprising an allergenic protein or glycoprotein crosslinked intermolecularly or intramolecularly with an inorganic cyanate. The modified material has reduced allergenicity relative to the uncrosslinked allergen and has the ability to produce antibodies having cross-specificity for the uncrosslinked allergenic protein or glycoprotein.
Inventors
- 👤 Noel Austin Mullan
- 👤 Brian George Overell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:21
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/36; A61K2039/60; A61K2039/6012; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
45 words
A PROCESS FOR THE PREPARATION OF A MODIFIED ALLERGENIC MATERIAL WHICH COMPRISES AN ALLERGENIC EXTRACT OF POLLEN OR HOUSE DUST WHICH CONSISTS PRINCIPALLY OF A PROTEIN OR GLYCOPROTEIN, WHICH COMPRISES REACTING AN ALLERGENIC EXTRACT OF POLLEN OR HOUSE DUST WITH AN EPIHALOHYDRIN OF THE FORMULA
Claim 2
Dependent Claim
45 words
A PROCESS FOR THE PREPARATION OF A MODIFIED ALLERGENIC MATERIAL WHICH COMPRISES AN ALLERGENIC EXTRACT OF POLLEN OR HOUSE DUST WHICH CONSISTS PRINCIPALLY OF A PROTEIN OR GLYCOPROTEIN, WHICH COMPRISES REACTING AN ALLERGENIC EXTRACT OF POLLEN OR HOUSE DUST WITH AN EPIHALOHYDRIN OF THE FORMULA
Claim 3
Dependent Claim
13 words
A process according to claim 1 wherein the temperature is below 100* C.
Claim 4
Dependent Claim
12 words
A process according to claim 1 wherein the pH is about 8.
Claim 5
Dependent Claim
13 words
A process according to claim 2 wherein the temperature is about room temperature.
Claim 6
Dependent Claim
12 words
A process according to claim 1 wherein X is bromine or chlorine.
Claim 7
Dependent Claim
10 words
A process according to claim 5 wherein X is bromine.
Claim 8
Dependent Claim
10 words
A process according to claim 5 wherein X is chlorine.
Claim 9
Dependent Claim
11 words
A process according to claim 1 wherein the epihalohydrin is 1-chloro-2:3-epoxypropane.
Claim 10
Dependent Claim
11 words
A process according to claim 1 wherein the eiphalohydrin is 1-bromo-2:3-epoxypropane.
Claim 11
Dependent Claim
14 words
A process according to claim 1 wherein the allergenic extract is a pollen extract.
Claim 12
Dependent Claim
15 words
A process according to claim 1 wherein the allergenic extract is a house dust extract.
Claim 13
Dependent Claim
12 words
A process according to claim 10 wherein the pollen is Cocksfoot pollen.
Claim 14
Dependent Claim
13 words
A process according to claim 10 wherein the pollen is mixed grass pollens.
Claim 15
Dependent Claim
12 words
A process according to claim 10 wherein the pollen is timothy pollen.
Claim 16
Dependent Claim
37 words
A modified allergenic material which comprises an allergenic extract of a pollen or house dust which consists principally of a protein or glycoprotein, which allergenic extract is crosslinked inter- or intra-molecularly with an epihalohydrin of the formula
Claim 17
Dependent Claim
37 words
A modified allergenic material which comprises an allergenic extract of a pollen or house dust which consists principally of a protein or glycoprotein, which allergenic extract is crosslinked inter- or intra-molecularly with an epihalohydrin of the formula
Claim 18
Dependent Claim
16 words
A modified allergenic material according to claim 15 wherein the allergenic extract is a pollen extract.
Claim 19
Dependent Claim
17 words
A modified allergenic material according to claim 15 wherein the allergenic extract is a house dust extract.
Claim 20
Dependent Claim
15 words
A modified allergenic material according to claim 15 wherein the epihalohydrin is of the formula
Claim 21
Dependent Claim
14 words
A modified allergenic material according to claim 18 wherein X is bromine or chlorine.
Claim 22
Dependent Claim
12 words
A modified allergenic material according to claim 19 wherein X is bromine.
Claim 23
Dependent Claim
12 words
A modified allergenic material according to claim 19 wherein X is chlorine.
Claim 24
Dependent Claim
13 words
A modified allergenic material according to claim 15 wherein the epihalohydrin is 1-chloro-2:3-epoxypropane.
Claim 25
Dependent Claim
13 words
A modified allergenic material according to claim 15 wherein the epihalohydrin is 1-bromo-2:3-epoxypropane.
Claim 26
Dependent Claim
14 words
A modified allergenic material according to claim 16 wherein the pollen is Cocksfoot pollen.
Claim 27
Dependent Claim
15 words
A modified allergenic material according to claim 16 wherein the pollen is mixed grass pollens.
Claim 28
Dependent Claim
14 words
A modified allergenic material according to claim 16 wherein the pollen is timothy pollen.
References Cited (Backward Citations)
US2882250A
Cited
US3794630A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-01 | 1979-03-03 | 1979-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-01 | 1983-03-03 | 1983-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-01 | 1987-03-03 | 1987-09-02 | $7700.00 | Window Closed / Lapsed |