Patent US3902849A successfully refreshed from Google Patents.
US3902849A
Expired / Lapsed
US
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Radioisotope and radiopharmaceutical generators
Assignee: United States Department of Energy
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Filing: 1973-07-30
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Granted: 1975-09-02
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Expires: 1993-07-30
Abstract
Abstract A chromatographic column for generating technetium-99m isotopes and technetium-99m labeled pharmaceuticals in a simple two-step process. Technetium-99m pertechnetate in a first step is isolated by adsorption upon an adsorbent packing. Then the technetium-99m in a second step is eluted from the packing, either with an immediately labeled biological compound to form a radiopharmaceutical, or by a controlled volume of eluant to produce a 99m-technetium-bearing eluate of a desired specific concentration.
Inventors
- 👤 Morton Barak
- 👤 Harry W Winchell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:14
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/60; G01N30/6091; A; A61; A61K; A61K51/00; A61K51/12; A61K51/1282; A61K2123/00; G01N30/50; G01N30/52; G01N30/6004; G01N30/603; G01N30/6034
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
139 words
A COLUMN FOR GENERATING A DAUGHTER RADIOISOTOPE FROM A PARENT COMPRISING: A TUBULAR SHELL, A FIRST LIQUID INLET AT ONE END OF SAID SHELL, A FIRST AND A SECOND POROUS DISC ENCLOSING A FIRST PACKED ZONE WITHIN SAID SHELL ADJACENT TO SAID FIRST INLET, PACKING WITHIN SAID FIRST PACKED ZONE COMPRISING AN ION EXCHANGE MEDIUM SUITABLE FOR ADSORBING SAID PARENT RADIOISOTOPE, A LIQUID OUTLET AT THE OTHER END OF SAID SHELL, A THIRD AND A FOURTH POROUS DISC ENCLOSING A SECOND PACKED ZONE WITHIN SAID SHELL INTERMEDIATE SAID FIRST PACKED ZONE AND SAID LIQUID OUTLET, A PACKING WITHIN SAID SECOND PACED ZONE SUITABLE FOR ADSORBING SAID DAUGHTER RADIOISOTOPE FREE OF ITS PARENT AND CONTAMINANTS, SAID ADSORBENT PACKING COMPRISING A REDUCING AGENT FOR SAID DAUGHTER RADIOISOTOPE, AND A SECOND LIQUID INLET FOR INTRODUCING ELUANT ONLY TO SAID SECOND PACKED ZONE.
Claim 2
Dependent Claim
139 words
A COLUMN FOR GENERATING A DAUGHTER RADIOISOTOPE FROM A PARENT COMPRISING: A TUBULAR SHELL, A FIRST LIQUID INLET AT ONE END OF SAID SHELL, A FIRST AND A SECOND POROUS DISC ENCLOSING A FIRST PACKED ZONE WITHIN SAID SHELL ADJACENT TO SAID FIRST INLET, PACKING WITHIN SAID FIRST PACKED ZONE COMPRISING AN ION EXCHANGE MEDIUM SUITABLE FOR ADSORBING SAID PARENT RADIOISOTOPE, A LIQUID OUTLET AT THE OTHER END OF SAID SHELL, A THIRD AND A FOURTH POROUS DISC ENCLOSING A SECOND PACKED ZONE WITHIN SAID SHELL INTERMEDIATE SAID FIRST PACKED ZONE AND SAID LIQUID OUTLET, A PACKING WITHIN SAID SECOND PACED ZONE SUITABLE FOR ADSORBING SAID DAUGHTER RADIOISOTOPE FREE OF ITS PARENT AND CONTAMINANTS, SAID ADSORBENT PACKING COMPRISING A REDUCING AGENT FOR SAID DAUGHTER RADIOISOTOPE, AND A SECOND LIQUID INLET FOR INTRODUCING ELUANT ONLY TO SAID SECOND PACKED ZONE.
Claim 3
Dependent Claim
27 words
The column of claim 1 wherein said reducing agent packing is selected from the group consisting of iron, tin and magnesium and said daughter radioisotope is technetium-99m.
References Cited (Backward Citations)
US2487574A
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US3462245A
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US3446965A
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US3657541A
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US3535085A
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US3785990A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-01 | 1979-03-03 | 1979-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-01 | 1983-03-03 | 1983-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-01 | 1987-03-03 | 1987-09-02 | $7700.00 | Window Closed / Lapsed |