Patent US2199204A successfully refreshed from Google Patents.
Patent US3902847A successfully refreshed from Google Patents.
US3902847A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic device and method for the diagnosis of mucoviscidosis (cystic fibrosis)
Assignee: Roche Diagnostics GmbH
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Filing: 1973-04-09
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Granted: 1975-09-02
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Expires: 1993-04-09
Abstract
Abstract Mucoviscidosis (cystic fibrosis) is detected in its early stages, particularly in the large-scale screening in newborn infants, by means of measuring the pathologically elevated protein content in the meconium, using a diagnostic agent comprising a protein test strip sealed to a longer plastic strip, applying meconium to the (flush) bottom portion of the combined strip, immersing the smeared portion of the strip in water, permitting water to wet the strip by ascending chromatography, and reading a color change in the strip as an indication of elevated protein content in the meconium.
Inventors
- 👤 Ernst-Werner Busch
- 👤 Hans Lange
- 👤 Hans-Georg Rey
- 👤 Walter Rittersdorf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:03
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525; G01N33/526; G01N33/68; G01N33/6803; G01N33/6827; G01N33/6839
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
53 words
DIAGNOSTIC DEVICE FOR DETECTING PATHALOGICALLY ELECVATED PROTEIN CONTENT IN MECONIUM COMPRISING A PROTEIN TEST STRIP SEALED OVER THE ENTIRE SURFACE AREA OF ONE OF ITS FACES TO A PLASTIC STRIP WHICH IS LONGER THAN THE TEST STRIP AND PROTRUDES THEREFROM, SAID TEST STRIP HAVING A LENGTH WHICH PROVIDES A SUFFICIENTLY GREAT CHROMATOGRAPHY AREA.
Claim 2
Dependent Claim
53 words
DIAGNOSTIC DEVICE FOR DETECTING PATHALOGICALLY ELECVATED PROTEIN CONTENT IN MECONIUM COMPRISING A PROTEIN TEST STRIP SEALED OVER THE ENTIRE SURFACE AREA OF ONE OF ITS FACES TO A PLASTIC STRIP WHICH IS LONGER THAN THE TEST STRIP AND PROTRUDES THEREFROM, SAID TEST STRIP HAVING A LENGTH WHICH PROVIDES A SUFFICIENTLY GREAT CHROMATOGRAPHY AREA.
Claim 3
Dependent Claim
38 words
Diagnostic device as claimed in claim 1 wherein said test strip is 4 to 10 mm. wide and 20 to 40, mm. long and the plastic strip is of the same width but 20 to 80 mm. longer.
Claim 4
Dependent Claim
31 words
Diagnostic device as claimed in claim 2 wherein the test strip is 5 to 6 mm. wide and 30 mm. long, and the plastic strip is 60 to 80 mm. long.
Claim 5
Dependent Claim
23 words
Diagnostic device is claimed in claim 1, wherein protein test strips are used which indicate the elevated protein content by intense blue coloration.
Claim 6
Dependent Claim
19 words
Diagnostic device as claimed in claim 1 wherein the plastic strip is a polyester stip about 0.19 mm. thick.
Claim 7
Dependent Claim
61 words
METHOD FOR THE DETECTION OF PATHOLOGICALLY ELEVATED PROTEIN CONTENT IN THE MECONIUM, COMPRISING APPLYING SOME MECONIUM TO THE BOTTOM PORTION OF A PROTEIN TEST STRIP AS CLAIMED IN CLAIM 1, THE STRIP IS THEN PLACED IN A VESSEL CONTAINING WATER, AND THE ELEVATED PROTEIN CONTENT IS READ ON THE PORTION OF THE TEST STRIP THAT HAS BEEN MOISTENED BY ASCENDING CHROMATOGRAPHY.
Claim 8
Dependent Claim
32 words
Method as claimed in claim 6 wherein the stip is placed in the water in such a manner that the water level is not above the test strip area smeared with meconium.
Claim 9
Dependent Claim
22 words
Method as claimed in claim 7 wherein at least three-quarters of said test paper is permitted to be wetted with the water.
Claim 10
Dependent Claim
68 words
Diagnostic device for detecting pathologically elevated protein content in meconium comprising a protein test strip sealed to a plastic strip which is longer than the test strip such that said plastic strip protrudes beyond the test strip at one end of the combined strip and is flush with the test strip at the other end, said test strip having the length which provides a sufficiently great chromatography area.
Claim 11
Dependent Claim
68 words
Diagnostic device for detecting pathologically elevated protein content in meconium comprising a protein test strip sealed to a plastic strip which is longer than the test strip such that said plastic strip protrudes beyond the test strip at one end of the combined strip and is flush with the test strip at the other end, said test strip having the length which provides a sufficiently great chromatography area.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-01 | 1979-03-03 | 1979-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-01 | 1983-03-03 | 1983-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-01 | 1987-03-03 | 1987-09-02 | $7700.00 | Window Closed / Lapsed |