US3901658A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Whole blood analysis rotor assembly having removable cellular sedimentation bowl
Assignee: United States Department of Energy
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Filing: 1974-07-30
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Granted: 1975-08-26
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Expires: 1994-07-30
Abstract
Abstract A rotor assembly for performing photometric analyses using whole blood samples. Following static loading of a gross blood sample within a centrally located, removable, cell sedimentation bowl, the red blood cells in the gross sample are centrifugally separated from the plasma, the plasma displaced from the sedimentation bowl, and measured subvolumes of plasma distributed to respective sample analysis cuvettes positioned in an annular array about the rotor periphery. Means for adding reagents to the respective cuvettes are also described.
Inventors
- 👤 Carl A Burtis
- 👤 Wayne F Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 19:51
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/01; G01N21/03; G01N21/07
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
219 words
AROTOR ASSEMBLY FOR A PHOTOMETRIC SOLUTION ANALYZER OF THE ROTARY CUVETTE TYPE SUITABLE FOR USE IN ANALYZING WHOLE BLOOD SAMPLES COMPRISING: A. A GENERALLY DISK-SHAPED MAIN ROTO BODY DEFINING I. AN ANNULAR PLASMA DISTRIBUTION MANIOLD. II. A PLURALITY OF VOLUME MEASURING CHAMBERS DISTRIBUTED IN A CIRCULAR ARRAY, SAID VOLUME MEASURING CHAMBERS BEING IN LIQUID FLOW COMMUNICATION WITH SAID PLASMA DISTRIBUTION MANIFOLD. III. MEANS LIMITING THE CENTRIPETAL LEVEL OF PLASMA IN SAID VOLUME MEASURING CHAMBERS DURING OPERATIONOOF SAID ROTOR, IV. A PLURALITY OF SAMPLE ANALYSIS CUVETTES DISPOSED IN A CIRCULAR ARRAY ABOUT THE PERIPHERY OF SAID MAIN ROTOR BODY, SAID SAMPLE ANALYSIS CUVETTES BEING IN LIQUID COMMUNICATION WITH SAID VOLUME MEASURING CHAMBERS, AND V. MEANS FOR LOADING REAGENTS INTO SAID SAMPLE ANALYSIS CUVETTES, AND B. A SEDIMENTATION BOWL NESTED WITHIN SAID MAIN ROTOR BODY AND ADAPTED TO ROTATE WITH THAT BODY AS A UNIT, SAID SEDIMENTATION BOWL COMPRISING: I. A HOLLOW DISK-SHAPED BASE PORTION, SAID BASE PORTION HAVING A CENTRALLY LOCATED TOP OPENING FOR RECEIVING WHOLE BLOOD SAMPLES AND DISCHARGING DISPLACED PLASMA, AND II AN UPSTANDING, OPEN-ENDED, ANNULAR NECK PORTION INTEGRALLY FIXED TO SAID BASE PORTION IN REGISTER WITH SAID TOP OPENING, THE TOP OF SAID NECK PORTION TERMINATING WITHIN THE CENTER OF SAID ANNULAR PLASMA DISTRIDUTION CHAMBER WITHIN A PLANE AXIALLY INTERMEDIATE TO THE AXIAL EXTREMITIES OF SUCH CHAMBER.
Claim 2
Dependent Claim
219 words
AROTOR ASSEMBLY FOR A PHOTOMETRIC SOLUTION ANALYZER OF THE ROTARY CUVETTE TYPE SUITABLE FOR USE IN ANALYZING WHOLE BLOOD SAMPLES COMPRISING: A. A GENERALLY DISK-SHAPED MAIN ROTO BODY DEFINING I. AN ANNULAR PLASMA DISTRIBUTION MANIOLD. II. A PLURALITY OF VOLUME MEASURING CHAMBERS DISTRIBUTED IN A CIRCULAR ARRAY, SAID VOLUME MEASURING CHAMBERS BEING IN LIQUID FLOW COMMUNICATION WITH SAID PLASMA DISTRIBUTION MANIFOLD. III. MEANS LIMITING THE CENTRIPETAL LEVEL OF PLASMA IN SAID VOLUME MEASURING CHAMBERS DURING OPERATIONOOF SAID ROTOR, IV. A PLURALITY OF SAMPLE ANALYSIS CUVETTES DISPOSED IN A CIRCULAR ARRAY ABOUT THE PERIPHERY OF SAID MAIN ROTOR BODY, SAID SAMPLE ANALYSIS CUVETTES BEING IN LIQUID COMMUNICATION WITH SAID VOLUME MEASURING CHAMBERS, AND V. MEANS FOR LOADING REAGENTS INTO SAID SAMPLE ANALYSIS CUVETTES, AND B. A SEDIMENTATION BOWL NESTED WITHIN SAID MAIN ROTOR BODY AND ADAPTED TO ROTATE WITH THAT BODY AS A UNIT, SAID SEDIMENTATION BOWL COMPRISING: I. A HOLLOW DISK-SHAPED BASE PORTION, SAID BASE PORTION HAVING A CENTRALLY LOCATED TOP OPENING FOR RECEIVING WHOLE BLOOD SAMPLES AND DISCHARGING DISPLACED PLASMA, AND II AN UPSTANDING, OPEN-ENDED, ANNULAR NECK PORTION INTEGRALLY FIXED TO SAID BASE PORTION IN REGISTER WITH SAID TOP OPENING, THE TOP OF SAID NECK PORTION TERMINATING WITHIN THE CENTER OF SAID ANNULAR PLASMA DISTRIDUTION CHAMBER WITHIN A PLANE AXIALLY INTERMEDIATE TO THE AXIAL EXTREMITIES OF SUCH CHAMBER.
Claim 3
Dependent Claim
18 words
The rotor assembly of claim 1 wherein said sedimentation bowl is removably nested within said main rotor body.
Claim 4
Dependent Claim
102 words
The rotor assembly of claim 1 further including a plurality of passageways communicating between said sample analysis cuvettes and said volume measuring chambers, each of said passageways comprising three radially extending interconnected passageway segments; a first segment extending radially from a respective sample analysis cuvette to a point centripetal to the centripetal ends of said volume measuring chambers, a second segment extending from the centripetal end of said first segment to a point centrifugal to said volume measuring chambers, and a third segment extending from the centrifugal end of said second segment to the centrifugal end of a respective volume measuring chamber.
Claim 5
Dependent Claim
38 words
The rotor assembly of claim 1 wherein said volume measuring chambers are axially displaced from said plasma distribution manifold with the centripetal ends of said volume measuring chambers radially overlapping the centrifugal extremity of said plasma distribution manifold.
Claim 6
Dependent Claim
41 words
The rotor assembly of claim 4 wherein axially extending plasma inlet ports communicate between said plasma distribution manifold and respective volume measuring chambers, said inlet ports being disposed on a common radius about the center of rotation of said rotor assembly.
Claim 7
Dependent Claim
41 words
The rotor assembly of claim 5 wherein said means limiting the centripetal level of plasma in said volume measuring chambers comprises a plasma overflow chamber and a plasma overflow passageway communicating between said plasma distribution manifold and said plasma overflow chamber.
Claim 8
Dependent Claim
32 words
The rotor assembly of claim 6 wherein said overflow passageway communicates with said plasma distribution manifold at a radius centripetal to the common radius on which said plasma inlet ports are disposed.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-25 | 1979-02-24 | 1979-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-25 | 1983-02-24 | 1983-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-25 | 1987-02-24 | 1987-08-26 | $7700.00 | Window Closed / Lapsed |