Chewable smoking substitute composition

Claim 2

A CHEWABLE ''''SUBSTITUTE FOR SMOKING'''' GEM COMPOSITION COMPRISING

Claim 3

A CHEWING GUM BASE AND

Claim 4

A CHEWING GUM BASE AND

Claim 5

NICOTINE, HELD BY A SALIVA-INSOLUBLE CATION EXCHANGER, WHEREIN THE CATION EXCHANGER IS SELECTED FROM THE GROUP CONSISTING OF A) METHACRYLIC TYPE, WEAKLY ACIDIC, CONTAINING CARBOXYLIC FUNCTIONAL GROUPS: B) POLYSTYRENE TYPE, STRONGLY ACIDIC, CONTAINING SULFONIC FUNCTIONAL GROUPS: AND C) POLYSTYRENE TYPE, HAVING INTERMEDIATE ACIDITY, CONTAINING PHOSPHONIC FUNCTIONAL GROUPS: SUBSTANTIALLY UNIFORMALY DISTRIBUTED IN SAID CHEWING GUM BASE, WHEREIN: A. THE COMPOSITION IS IN THE FORM OF A CHEWABLE GUM UNIT WEIGHING IN THE RANGE OF ABOUT 0.5 TO ABOUT 4 GRAMS: B. THE CHEWING GUM BASE IS PRESENT IN SAID GUM COMPOSITION IN AMOUNT IN THE RANGE OF ABOUT 15 TO ABOUT 80 WEIGHT PERCENT OF SAID GUM COMPOSITION: C. THE NICOTINE IS PRESENT IN SAID COMPOSITION IN AN AMOUNT IN THE RANGE OF ABOUT 0.05 WEIGHT PERCENT TO ABOUT 2 WEIGHT PERCENT BASED ON THE WEIGHT OF THE CHEWING GUM BASE AND CALCULATED AS THE FREE BASE: D. THE AMOUNT OF NICOTINE HELD BY THE CATION EXCHANGER AND DISTRIBUTED IN SAID CHEWING GUM BASE IS IN THE RANGE OF ABOUT 1 TO ABOUT 10 MILLIGRAMS, SUCH AMOUNT OF NICOTINE APPROXIMATING THE AMOUNT AVAILABLE UPON SMOKING A SMOKING TOBACCO PRODUCT, E. SAID NICOTINE-CATION EXCHANGE COMPLEX CONSTITUTFES UP TO ABOUT 10 PERCENT BY WEIGHT OF SAID CHEWING GUM COMPOSITION, F. THE NICOTINE IS PRESENT IN SAID NICOTINE-CATION EXCHANGE COMPLEX IN AN AMOUNT IN THE RANGE OF ABOUT 2 TO 60 PERCENT BY WEIGHT G. THE NICOTINE HELD BY SAID SILIVA-INSOLUBLE CATION EXCHANGER BEING PERCENT IN SAID GUM COMPOSITION AS A NICOTINE-CATION EXCHANGE COMPLEX WHICH UPON CHEWING LIBERATES THE NICOTINE CATION, AND H. SAID CHEWING GUM COMPOSITION WHEN CHEWING RELEASING NICOTINE IN SMALL AND REDUCED AMOUNT WITHIN A PERIOD OF THE FIRST FEW MINUTES OF CHEWING, AND I. ESPECIALLY WITHIN THE FIRST TEN MINUTES OF CHEWING RELEAAASIN THE NICOTINE AT A RATE LESS THAN IF THE NICOTINE WERE PRESENT BY ITSELF IN AN ORDINARY GUM COMPOSITION AND LESS THAN IF THE NICOTINE-CATION EXCHANGER COMPLEX WERE USED BY ITSELF ABSENT THE GUM.

Claim 6

NICOTINE, HELD BY A SALIVA-INSOLUBLE CATION EXCHANGER, WHEREIN THE CATION EXCHANGER IS SELECTED FROM THE GROUP CONSISTING OF A) METHACRYLIC TYPE, WEAKLY ACIDIC, CONTAINING CARBOXYLIC FUNCTIONAL GROUPS: B) POLYSTYRENE TYPE, STRONGLY ACIDIC, CONTAINING SULFONIC FUNCTIONAL GROUPS: AND C) POLYSTYRENE TYPE, HAVING INTERMEDIATE ACIDITY, CONTAINING PHOSPHONIC FUNCTIONAL GROUPS: SUBSTANTIALLY UNIFORMALY DISTRIBUTED IN SAID CHEWING GUM BASE, WHEREIN: A. THE COMPOSITION IS IN THE FORM OF A CHEWABLE GUM UNIT WEIGHING IN THE RANGE OF ABOUT 0.5 TO ABOUT 4 GRAMS: B. THE CHEWING GUM BASE IS PRESENT IN SAID GUM COMPOSITION IN AMOUNT IN THE RANGE OF ABOUT 15 TO ABOUT 80 WEIGHT PERCENT OF SAID GUM COMPOSITION: C. THE NICOTINE IS PRESENT IN SAID COMPOSITION IN AN AMOUNT IN THE RANGE OF ABOUT 0.05 WEIGHT PERCENT TO ABOUT 2 WEIGHT PERCENT BASED ON THE WEIGHT OF THE CHEWING GUM BASE AND CALCULATED AS THE FREE BASE: D. THE AMOUNT OF NICOTINE HELD BY THE CATION EXCHANGER AND DISTRIBUTED IN SAID CHEWING GUM BASE IS IN THE RANGE OF ABOUT 1 TO ABOUT 10 MILLIGRAMS, SUCH AMOUNT OF NICOTINE APPROXIMATING THE AMOUNT AVAILABLE UPON SMOKING A SMOKING TOBACCO PRODUCT, E. SAID NICOTINE-CATION EXCHANGE COMPLEX CONSTITUTFES UP TO ABOUT 10 PERCENT BY WEIGHT OF SAID CHEWING GUM COMPOSITION, F. THE NICOTINE IS PRESENT IN SAID NICOTINE-CATION EXCHANGE COMPLEX IN AN AMOUNT IN THE RANGE OF ABOUT 2 TO 60 PERCENT BY WEIGHT G. THE NICOTINE HELD BY SAID SILIVA-INSOLUBLE CATION EXCHANGER BEING PERCENT IN SAID GUM COMPOSITION AS A NICOTINE-CATION EXCHANGE COMPLEX WHICH UPON CHEWING LIBERATES THE NICOTINE CATION, AND H. SAID CHEWING GUM COMPOSITION WHEN CHEWING RELEASING NICOTINE IN SMALL AND REDUCED AMOUNT WITHIN A PERIOD OF THE FIRST FEW MINUTES OF CHEWING, AND I. ESPECIALLY WITHIN THE FIRST TEN MINUTES OF CHEWING RELEAAASIN THE NICOTINE AT A RATE LESS THAN IF THE NICOTINE WERE PRESENT BY ITSELF IN AN ORDINARY GUM COMPOSITION AND LESS THAN IF THE NICOTINE-CATION EXCHANGER COMPLEX WERE USED BY ITSELF ABSENT THE GUM.

Claim 7

The chewing gum composition of claim 1 wherein the amount of nicotine held by said cation exchanger and distributed in said chewing gum base is in the range of about 1 to about 5 milligrams, such amount of nicotine approximating that available upon smoking a cigarette.

Claim 8

nicotine, held by a saliva-insoluble cation exchanger, substantially uniformly distributed in said chewing gum base, wherein: A. the composition is in the form of a chewable gum unit weighing in the range of about 0.5 to about 4 grams; B. the chewing gum base is present in said gum composition in an amount in the range of about 15 to about 80 weight percent of said gum composition; C. the nicotine is present in said composition in an amount in the range of about 0.05 weight percent to about 2 weight percent based on the weight of the chewing gum base and calculated as the free base; D. the amount of nicotine held by the cation exchanger and distributed in said chewing gum base is in the range of about 1 to about 10 milligrams, such amount of nicotine approximating the amount available upon smoking a smoking tobacco product; E. said nicotine-cation exchange complex constitutes up to about 10 percent by weight of said chewing gum composition; F. the nicotine is present in said nicotine-cation exchange complex in an amount in the range of about 2 to about 60 percent by weight; G. the nicotine held by said saliva-insoluble cation exchanger being present in said gum composition as a nicotine-cation exchange complex which upon chewing liberates the nicotine cation, and H. said chewing gum composition when chewed releasing nicotine in small and reduced amounts within a period of the first few minutes of chewing, and I. especially within the first ten minutes of chewing releasing the nicotine at a rate less than if the nicotine were present by itself in an ordinary gum composition and less than if the nicotine-cation exchanger complex were used by itself absent the gum.

Claim 9

nicotine, held by a saliva-insoluble cation exchanger, substantially uniformly distributed in said chewing gum base, wherein: A. the composition is in the form of a chewable gum unit weighing in the range of about 0.5 to about 4 grams; B. the chewing gum base is present in said gum composition in an amount in the range of about 15 to about 80 weight percent of said gum composition; C. the nicotine is present in said composition in an amount in the range of about 0.05 weight percent to about 2 weight percent based on the weight of the chewing gum base and calculated as the free base; D. the amount of nicotine held by the cation exchanger and distributed in said chewing gum base is in the range of about 1 to about 10 milligrams, such amount of nicotine approximating the amount available upon smoking a smoking tobacco product; E. said nicotine-cation exchange complex constitutes up to about 10 percent by weight of said chewing gum composition; F. the nicotine is present in said nicotine-cation exchange complex in an amount in the range of about 2 to about 60 percent by weight; G. the nicotine held by said saliva-insoluble cation exchanger being present in said gum composition as a nicotine-cation exchange complex which upon chewing liberates the nicotine cation, and H. said chewing gum composition when chewed releasing nicotine in small and reduced amounts within a period of the first few minutes of chewing, and I. especially within the first ten minutes of chewing releasing the nicotine at a rate less than if the nicotine were present by itself in an ordinary gum composition and less than if the nicotine-cation exchanger complex were used by itself absent the gum.

Claim 10

nicotine, held by a saliva-insoluble cation exchanger, wherein the cation exchanger is selected from the group consisting of a) methacrylic type, weakly acidic, containing carboxylic functional groups; b) polystyrene type, strongly acidic, containing sulfonic functional groups; and c) polystyrene type, having intermediate acidity, containing phosphonic functional groups; substantially uniformly distributed in said chewing gum base, wherein: A. the composition is in the form of a chewable gum unit weighing in the range of about 0.5 to about 4 grams; B. the chewing gum base is present in said gum composition in an amount in the range of about 15 to about 80 weight percent of said gum composition; C. the nicotine is present in said composition in an amount in the range of about 0.05 weight percent to about 2 weight percent based on the weight of the chewing gum base and calculated as the free base; D. the amount of nicotine held by the cation exchanger and distributed in said chewing gum base is in the range of about 1 to about 10 milligrams, such amount of nicotine approximating the amount available upon smoking a smoking tobacco product; E. said nicotine-cation exchange complex constitutes up to about 10 percent by wEight of said chewing gum composition; F. the nicotine is present in said nicotine-cation exchange complex in an amount in the range of about 2 to about 60 percent by weight; G. the nicotine held by said saliva-insoluble cation exchanger being present in said gum composition as a nicotine-cation exchanger complex which upon chewing liberates the nicotine cation, and H. said chewing gum composition when chewed releasing nicotine in small and reduced amounts within a period of the first few minutes of chewing, and I. especially within the first ten minutes of chewing releasing the nicotine at a rate less than if the nicotine were present by itself in an ordinary gum composition and less than if the nicotine-cation exchanger complex were used by itself absent the gum.

Claim 11

nicotine, held by a saliva-insoluble cation exchanger, wherein the cation exchanger is selected from the group consisting of a) methacrylic type, weakly acidic, containing carboxylic functional groups; b) polystyrene type, strongly acidic, containing sulfonic functional groups; and c) polystyrene type, having intermediate acidity, containing phosphonic functional groups; substantially uniformly distributed in said chewing gum base, wherein: A. the composition is in the form of a chewable gum unit weighing in the range of about 0.5 to about 4 grams; B. the chewing gum base is present in said gum composition in an amount in the range of about 15 to about 80 weight percent of said gum composition; C. the nicotine is present in said composition in an amount in the range of about 0.05 weight percent to about 2 weight percent based on the weight of the chewing gum base and calculated as the free base; D. the amount of nicotine held by the cation exchanger and distributed in said chewing gum base is in the range of about 1 to about 10 milligrams, such amount of nicotine approximating the amount available upon smoking a smoking tobacco product; E. said nicotine-cation exchange complex constitutes up to about 10 percent by wEight of said chewing gum composition; F. the nicotine is present in said nicotine-cation exchange complex in an amount in the range of about 2 to about 60 percent by weight; G. the nicotine held by said saliva-insoluble cation exchanger being present in said gum composition as a nicotine-cation exchanger complex which upon chewing liberates the nicotine cation, and H. said chewing gum composition when chewed releasing nicotine in small and reduced amounts within a period of the first few minutes of chewing, and I. especially within the first ten minutes of chewing releasing the nicotine at a rate less than if the nicotine were present by itself in an ordinary gum composition and less than if the nicotine-cation exchanger complex were used by itself absent the gum.

Claim 12

A chewable ''''substitute for smoking'''' gum composition comprising

Claim 13

A chewable ''''substitute for smoking'''' gum composition comprising

Claim 14

The chewing gum composition of claim 3 wherein the amount of nicotine held by said cation exchanger and distributed in said chewing gum base is in the range of about 1 to about 5 milligrams, such amount of nicotine approximating that available upon smoking a cigarette.