Patent US3900476A successfully refreshed from Google Patents.
US3900476A
Expired / Lapsed
US
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2(2'-pyrimidylamino)quinazolines and their preparation
Assignee: Pharmacia and Upjohn Co
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Filing: 1973-05-17
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Granted: 1975-08-19
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Expires: 1993-05-17
Abstract
Abstract Novel Compounds of formula: AND THE ACID ADDITION SALTS THEREOF ARE DISCLOSED WHEREIN X and Y are each selected from hydrogen, halogen, lower alkyl and lower alkoxy. R represents lower alkyl while n is an integer of from 0 to 1, inclusive. Disclosed also are methods of preparing and using the novel compounds of the invention which are useful in vitro antiviral agents.
Inventors
- 👤 Harold E Renis
- 👤 Louis L Skaletzky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 06:48
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
7 words
A COMPOUND SELECTED FROM THOSE OF FORMULA:
Claim 2
Dependent Claim
7 words
A COMPOUND SELECTED FROM THOSE OF FORMULA:
Claim 3
Dependent Claim
7 words
A compound selected from those of formula:
Claim 4
Dependent Claim
7 words
A compound selected from those of formula:
Claim 5
Dependent Claim
9 words
A compound according to claim 2 which is 2-(2-imidazolin-2-ylamino)-4-methylquinazoline.
Claim 6
Dependent Claim
10 words
A compound according to claim 2 which is 2-(2-imidazolin-2-ylamino)-4-methylquinazolinE hydrochloride.
Claim 7
Dependent Claim
11 words
A compound according to claim 2 which is 2-(2-imidazolin-2-ylamino)-4-methylquinazoline hydrochloride hydrate.
Claim 8
Dependent Claim
28 words
A process which comprises the step of heating within a temperature range of from about 100*C. to about 200*C. a mixture of i. a compound of the formula:
Claim 9
Dependent Claim
28 words
A process which comprises the step of heating within a temperature range of from about 100*C. to about 200*C. a mixture of i. a compound of the formula:
Claim 10
Dependent Claim
17 words
A process according to claim 6 wherein said strong acid employed as a catalyst in p-toluenesulfonic acid.
Claim 11
Dependent Claim
29 words
A process according to claim 6 wherein said strong acid is added to said mixture in the form of the mono-acid salt of said acid and the diamine (ii).
Claim 12
Dependent Claim
19 words
A process according to claim 8 wherein said salt is the salt of mono-p-toluenesulfonic acid and a diamine (ii).
Claim 13
Dependent Claim
12 words
A process according to claim 8 wherein said salt is ethylenediamine mono-p-toluenesulfonate.
Claim 14
Dependent Claim
25 words
A process according to claim 6 wherein said compound (i) is 4-methyl-2-quinazolinecarbamonitrile, said diamine (ii) is ethylenediamine and the product of the process is 2-(2-imidazolin-2-ylamino)-4-methylquinazoline.
Claim 15
Dependent Claim
24 words
A process according to claim 6 wherein said thiol compound is employed in a proportion of from about 0.05 equivalent to about 0.2 equivalent.
Claim 16
Dependent Claim
13 words
A process according to claim 6 wherein said thiol compound is Alpha -toluenethiol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-08-18 | 1979-02-17 | 1979-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-08-18 | 1983-02-17 | 1983-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-08-18 | 1987-02-17 | 1987-08-19 | $7700.00 | Window Closed / Lapsed |