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Process for producing implantable, porous, ceramic, bone substitution, bone connection or prosthesis anchoring materials

Assignee: GERMAN FEDERAL REPUBLIC REPRES
•
Filing: 1973-08-31
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Granted: 1975-08-12
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Expires: 1993-08-31
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Abstract

Abstract A process for producing an implantable, porous, ceramic bone substitution or bone connection or prosthesis anchoring material, and the like, which has open pores of substantially regular or uniform size, distribution and disposition. The process includes (a) producing a frame which corresponds approximately to the pores and pore connections of the desired finished product, (b) filling the frame with a physiologically suitable and biologically compatible castable or pourable ceramic mass, and (c), after at least a partial hardening of the ceramic mass, dismantling or decomposing and removing the frame, whereby said finished raw product or said ceramic material is obtained. The finished product can be used for the permenant or temporary replacement of bone matter.

Inventors

  • 👤 Helmut Heide
  • 👤 Ulrich Hoffmann
  • 👤 Gunther Brotz
  • 👤 Eva Poeschel

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 04:40
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/56; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/40; A61L27/44; Y; Y10; Y10S; Y10S264/00; Y10S264/44; Y10S623/00; Y10S623/92; Y10S623/923

Claims Analysis

Total Claims: 24
Claim 1
Independent Claim 222 words
THE PROCESS FOR PRODUCING AN IMPLANTABLE, POROUS, CERMAIC BONE SUBSTITUTION- OR BONE CONNECTION - OR PROSTHESIS ANCHORING MATERIAL, AND THE LIKE, WHICH HAS OPEN PORES OF SUBSTANTIALLY REGUALR OR UNIFORM SIZE, DISTRIBUTION AND DISPOSITION WHICH COMPRISES: (A) PRODUCING A FRAME WHICH CORRESPONDS APPROXIMATELY TO THE PORES AND PORE INTERCONNECTIONS OF THE DESIRED FINISHED PRODUCT, THE FRAME BEING FORMED BY PREPARING A COMPACT ARRANGEMENT OF SPHERICAL BODIES, WHICH ARE APPROXIMATELY OF EQUAL OR UNIFORM SIZE, FILLING SAID COMPACT ARRANGEMENT OF SPHERICAL BODIES WITH A LIQUID WHICH GRADUALLY, GENTLY DISSOLVES SAID BODIES, SAID LIQUID GRADUALLY, GENTLY DISSOLVING PART OF SAID FILLER BODIES, THE TIME OF DISSOLVING BEING SUFFICIENT TO DISSOLVE ENOUGH OF SAID FILLER BODIES SO THAT BRIDGES OF THE DISSOLVED PORTION OF SAID FILLER BODIES CAN FORM BRIDGES AFTER SAID LIQUID IS REMOVED, AND REMOVING SAID LIQUID SO THAT A LIQUID FILM REMAINS ON SAID BODIES, SAID FILM CONSTITUTING A LIQUID MEDIUM MENISCUS AT THE POINTS OR EDGES OF CONTACT OF SAID BODIES, WHEREBY BRIDGES OF SAID DISSOLVED PORTION SAID FILLER BODIES FORM BETWEEN SAID FILLER BODIES, (D) FILLING THE FRAME WITH A PHYSIOLOGICALLY SUITABLE AND BIOLOGICALLY COMPATIBLE CASTABLE OR POURABLE CERMAIC MASS, AND (C), AFTER AT LEAST A PARTIAL HARDENING OF THE CERAMIC MASS, DISMANTING OR DECOMPOSING AND REMOVING THE FRAME, WHEREBY SAID DESIRED FINISHED PRODUCT OR SAID CERAMIC MATERIAL IS OBTAINED.
Claim 2
Dependent Claim 222 words
THE PROCESS FOR PRODUCING AN IMPLANTABLE, POROUS, CERMAIC BONE SUBSTITUTION- OR BONE CONNECTION - OR PROSTHESIS ANCHORING MATERIAL, AND THE LIKE, WHICH HAS OPEN PORES OF SUBSTANTIALLY REGUALR OR UNIFORM SIZE, DISTRIBUTION AND DISPOSITION WHICH COMPRISES: (A) PRODUCING A FRAME WHICH CORRESPONDS APPROXIMATELY TO THE PORES AND PORE INTERCONNECTIONS OF THE DESIRED FINISHED PRODUCT, THE FRAME BEING FORMED BY PREPARING A COMPACT ARRANGEMENT OF SPHERICAL BODIES, WHICH ARE APPROXIMATELY OF EQUAL OR UNIFORM SIZE, FILLING SAID COMPACT ARRANGEMENT OF SPHERICAL BODIES WITH A LIQUID WHICH GRADUALLY, GENTLY DISSOLVES SAID BODIES, SAID LIQUID GRADUALLY, GENTLY DISSOLVING PART OF SAID FILLER BODIES, THE TIME OF DISSOLVING BEING SUFFICIENT TO DISSOLVE ENOUGH OF SAID FILLER BODIES SO THAT BRIDGES OF THE DISSOLVED PORTION OF SAID FILLER BODIES CAN FORM BRIDGES AFTER SAID LIQUID IS REMOVED, AND REMOVING SAID LIQUID SO THAT A LIQUID FILM REMAINS ON SAID BODIES, SAID FILM CONSTITUTING A LIQUID MEDIUM MENISCUS AT THE POINTS OR EDGES OF CONTACT OF SAID BODIES, WHEREBY BRIDGES OF SAID DISSOLVED PORTION SAID FILLER BODIES FORM BETWEEN SAID FILLER BODIES, (D) FILLING THE FRAME WITH A PHYSIOLOGICALLY SUITABLE AND BIOLOGICALLY COMPATIBLE CASTABLE OR POURABLE CERMAIC MASS, AND (C), AFTER AT LEAST A PARTIAL HARDENING OF THE CERAMIC MASS, DISMANTING OR DECOMPOSING AND REMOVING THE FRAME, WHEREBY SAID DESIRED FINISHED PRODUCT OR SAID CERAMIC MATERIAL IS OBTAINED.
Claim 3
Dependent Claim 30 words
The process according to claim 1 wherein substantially all of said filler bodies, said resultant open pores and said pore interconnections have a diameter of at least 150 Mu m.
Claim 4
Dependent Claim 35 words
A process according to claim 2 wherein the frame material is a soluble or low melting salt, plastic, wax-like substance, metal or metal alloy, each of which has a low fusion point or is soluble.
Claim 5
Dependent Claim 33 words
The process according to claim 2 wherein the frame material is a substance which can be evaporated or burned at a temperature which is considerably below the sintering temperature of the ceramic mass.
Claim 6
Dependent Claim 47 words
The process according to claim 2 wherein the castable ceramic mass is a liquid-solid suspension of a material selected from the group consisting of a clay-bonded material, a ceramic material, an oxide-ceramic material, a glass-ceramic material or a vitreous material, and a suitable binder or cement-type additive.
Claim 7
Dependent Claim 13 words
The process according to claim 2 hwerein the castable ceramic mass contains Al2O3.
Claim 8
Dependent Claim 16 words
The process according to claim 2 wherein the frame is prepared from polystyrene, in particle form.
Claim 9
Dependent Claim 171 words
The process for producing an implantable, porous, ceramic bone substitution- or bone connection - or prosthesis anchoring material, and the like, which has open pores of substantially regular or uniform size, distribution and disposition which comprises: (a) producing a frame which corresponds approximately to the pores and pore interconnections of the desired finished product, the frame being formed by wettening or moistening spherical, approximately equally or uniformly sized filler bodies with an adhesive having a low viscosity, said filler bodies being low melting and having a melting point lower than said ceramic material, and bringing said filler bodies together in a compact arrangement, said filler bodies being glued or cemented together by the adhesive at the points or surfaces of contact of said filler bodies; (b) filling the frame with a physiologically suitable and biologically compatible castable or pourable ceramic mass; and (c) after at least a partial hardening of the ceramic mass, dismantling or decomposing and removing the frame, whereby said desired finished product or said ceramic material is obtained.
Claim 10
Dependent Claim 171 words
The process for producing an implantable, porous, ceramic bone substitution- or bone connection - or prosthesis anchoring material, and the like, which has open pores of substantially regular or uniform size, distribution and disposition which comprises: (a) producing a frame which corresponds approximately to the pores and pore interconnections of the desired finished product, the frame being formed by wettening or moistening spherical, approximately equally or uniformly sized filler bodies with an adhesive having a low viscosity, said filler bodies being low melting and having a melting point lower than said ceramic material, and bringing said filler bodies together in a compact arrangement, said filler bodies being glued or cemented together by the adhesive at the points or surfaces of contact of said filler bodies; (b) filling the frame with a physiologically suitable and biologically compatible castable or pourable ceramic mass; and (c) after at least a partial hardening of the ceramic mass, dismantling or decomposing and removing the frame, whereby said desired finished product or said ceramic material is obtained.
Claim 11
Dependent Claim 30 words
The process according to claim 8 wherein substantially all of said filler bodies, said resultant open pores and said pore interconnections have a diameter of at least 150 Mu m.
Claim 12
Dependent Claim 36 words
The process according to claim 9 wherein the frame material is a soluble or low melting salt, plastic, wax like, substance, metal or metal alloy, each of which has a low fusion point or is soluble.
Claim 13
Dependent Claim 33 words
The process according to claim 9 wherein the frame material is a substance which can be evaporated or burned at a temperature which is considerably below the sintering temperature of the ceramic mass.
Claim 14
Dependent Claim 47 words
The process according to claim 9 wherein the castable ceramic mass is a liquid-solid suspension of a material selected from the group consisting of a clay-bonded material, a ceramic material, an oxide-ceramic material, a glass-ceramic material or a vitreous material, and a suitable binder or cement-type additive.
Claim 15
Dependent Claim 13 words
The process according to claim 9 wherein the castable ceramic mass contains Al2O3.
Claim 16
Dependent Claim 16 words
The process according to claim 9 wherein the frame is prepared from polystyrene, in particle form.
Claim 17
Dependent Claim 174 words
The process for producing an implantable, porous, ceramic bone substitution- or bone connection - or prosthesis anchoring material, and the like, which has open pores of substantially regular or uniform size, distribution and disposition which comprises: (a) producing a frame which corresponds approximately to the pores and pore interconnections of the desired finished products, the frame being formed by preparing a compact arrangement of spherical, approximately equally or uniformly sized filler bodies, said filler bodies, being low melting and having a melting point lower than said ceramic material and sintering together said low-melting filler bodies at the points or surfaces of contact of said filler bodies by an increase in the temperature of said filler bodies to a temperature just below the melting point of said filler bodies; (b) filling the frame with a physiologically suitable and biologically compatible castable or pourable ceramic mass; and (c) after at least a partial hardening of the ceramic mass, dismantling or decomposing and removing the frame, whereby said desired finished product or said ceramic material is obtained.
Claim 18
Dependent Claim 174 words
The process for producing an implantable, porous, ceramic bone substitution- or bone connection - or prosthesis anchoring material, and the like, which has open pores of substantially regular or uniform size, distribution and disposition which comprises: (a) producing a frame which corresponds approximately to the pores and pore interconnections of the desired finished products, the frame being formed by preparing a compact arrangement of spherical, approximately equally or uniformly sized filler bodies, said filler bodies, being low melting and having a melting point lower than said ceramic material and sintering together said low-melting filler bodies at the points or surfaces of contact of said filler bodies by an increase in the temperature of said filler bodies to a temperature just below the melting point of said filler bodies; (b) filling the frame with a physiologically suitable and biologically compatible castable or pourable ceramic mass; and (c) after at least a partial hardening of the ceramic mass, dismantling or decomposing and removing the frame, whereby said desired finished product or said ceramic material is obtained.
Claim 19
Dependent Claim 31 words
The process according to claim 15 wherein substantially all of the said filler bodies, said resultant open pores and said pore interconnections have a diameter of at least 150 Mu m.
Claim 20
Dependent Claim 35 words
The process according to claim 16 wherein the frame material is a soluble or low melting salt, plastic, wax-like substance, metal or metal alloy, each of which has a low fusion point or is soluble.
Claim 21
Dependent Claim 33 words
The process according to claim 16 wherein the frame material is a substance which can be evaporated or burned at a temperature which is considerably below the sintering temperature of the ceramic mass.
Claim 22
Dependent Claim 47 words
The process according to claim 16 wherein the castable ceramic mass is a liquid-solid suspension of a material selected from the group consisting of a clay-bonded material, a ceramic material, an oxide-ceramic material, a glass-ceramic material or a vitreous material, and a suitable binder or cement-type additive.
Claim 23
Dependent Claim 13 words
The process according to claim 16 wherein the castable ceramic mass contains Al2O3.
Claim 24
Dependent Claim 16 words
The process according to claim 16 wherein the frame is prepared from polystyrene, in particle form.

References Cited (Backward Citations)

US2996389A Cited
US3097930A Cited
US3090094A Cited
US3176054A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-08-11 1979-02-10 1979-08-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-08-11 1983-02-10 1983-08-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-08-11 1987-02-10 1987-08-12 $7700.00 Window Closed / Lapsed

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