Patent US3897363A successfully refreshed from Google Patents.
US3897363A
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Blood control standard
Assignee: Baxter International Inc
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Filing: 1973-08-10
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Granted: 1975-07-29
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Expires: 1993-08-10
Abstract
Abstract A blood control standard is prepared from anticoagulant stored blood plasma containing elevated levels of dextrose by aerobic fermentation with yeast in the late log phase or in the stationery phase of the yeast growth to selectively destroy dextrose without adversely affecting the protein constituents of said blood plasma.
Inventors
- 👤 Allan L Louderback
- 👤 Anthony J Fontana
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 08:19
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; C; C12; C12Q; C12Q1/00; C12Q1/56; Y; Y10; Y10S; Y10S435/00; Y10S435/802; Y10S435/8215; Y10S435/911; Y10S435/94; Y10S435/942; Y10T; Y10T436/00; Y10T436/10; Y10T436/104998; Y10T436/106664; Y10T436/107497; Y10T436/108331
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
68 words
THE METHOD OF MAKING A BLOOD CONTROL STANDARD FROM ANTICOAGULANT STORED, DEFIBRINATED BLOOD PLASMA CONTAINING ELEVATED LEVELS OF DEXTROSE WHICH COMPRISES SELECTIVELY DESTROYING DEXTROSE IN SAID BLOOD PLASMA BY AEROBIC FERMENTATION WITH AGITATION UTILIZING 0.1 TO 10 GRAMS OF A YEAST IN THE NEGATIVE ACCELERATION PHASE OR IN THE STATIONARY PHASE OF THE YEAST GROWTH PER LITER OF SAID PLASMA AND SEPARATING PARTICULATE RESIDUE FROM THE FERMENTATION PRODUCT.
Claim 2
Independent Claim
68 words
THE METHOD OF MAKING A BLOOD CONTROL STANDARD FROM ANTICOAGULANT STORED, DEFIBRINATED BLOOD PLASMA CONTAINING ELEVATED LEVELS OF DEXTROSE WHICH COMPRISES SELECTIVELY DESTROYING DEXTROSE IN SAID BLOOD PLASMA BY AEROBIC FERMENTATION WITH AGITATION UTILIZING 0.1 TO 10 GRAMS OF A YEAST IN THE NEGATIVE ACCELERATION PHASE OR IN THE STATIONARY PHASE OF THE YEAST GROWTH PER LITER OF SAID PLASMA AND SEPARATING PARTICULATE RESIDUE FROM THE FERMENTATION PRODUCT.
Claim 3
Dependent Claim
12 words
The method of claim 1 in which the yeast is Saccharomyces cerevisiae.
Claim 4
Dependent Claim
29 words
The method of claim 1 in which the blood plasma is incubated with the yeast for about 12 to about 24 hours at about 20* to about 25* C.
Claim 5
Dependent Claim
41 words
The method of claim 1 in which the dextrose in said blood plasma is reduced from an initial level of about 300 to 500 mg. per 100 ml. to a final level of about 0 to 50 mg. per 100 ml.
Claim 6
Dependent Claim
71 words
The method of claim 1 in which the yeast is Saccharomyces cerevisiae, the blood plasma is incubated with said yeast for about 12 to about 24 hours at about 20* to about 25* C, and in which the dextrose in said blood plasma is reduced from an initial level of about 300 to 500 mg. per 100 ml. to a final level of about 0 to 50 mg. per 100 ml.
Claim 7
Dependent Claim
86 words
A liquid blood control standard comprising anticoagulant-stored blood plasma containing from about 300 to 500 mg. per 100 ml. of dextrose which is defibrinated, reacted with yeast by aerobic fermentation with agitation utilizing from 0.1 to 10 grams of said yeast per liter of said plasma in the negative acceleration phase or in the stationary phase of the yeast growth to selectively destroy said dextrose and reduce its concentration to a level of about 0 to 50 mg. per 100 ml, and seParated from particulate residue.
Claim 8
Dependent Claim
86 words
A liquid blood control standard comprising anticoagulant-stored blood plasma containing from about 300 to 500 mg. per 100 ml. of dextrose which is defibrinated, reacted with yeast by aerobic fermentation with agitation utilizing from 0.1 to 10 grams of said yeast per liter of said plasma in the negative acceleration phase or in the stationary phase of the yeast growth to selectively destroy said dextrose and reduce its concentration to a level of about 0 to 50 mg. per 100 ml, and seParated from particulate residue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-07-28 | 1979-01-27 | 1979-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-07-28 | 1983-01-27 | 1983-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-07-28 | 1987-01-27 | 1987-07-29 | $7700.00 | Window Closed / Lapsed |